Statin-Associated Autoimmune Myopathy
Abstract
Statins are widely used and lower the risk of death from cardiovascular causes. In a fraction of patients, an autoimmune myopathy may develop, characterized by the development of autoantibodies to the target enzyme, HMG-CoA reductase.
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A reduction in cholesterol biosynthesis in the liver also results in a decrease in the TG level through simultaneous suppression of VLDL synthesis and secretion, with a decrease ranging from approximately 10%-20%.
“Although a reduction in cholesterol biosynthesis in the liver also results in a decrease in the TG level through simultaneous suppression of very low-density lipoprotein (VLDL) synthesis and secretion659), the decrease ranges from approximately 10%–20%.”
From Japan Atherosclerosis Society (JAS) guidelines for prevention of atherosclerotic cardiovascular diseases 2017 (2018) · cites this paper as [659]
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References 38 · Cited by 366
- Authors
- Mammen, A. L.
- Corresponding author
- Mammen, Andrew L.
- ORCID
- Mammen, Andrew L.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2016-02-18
- Volume
- 374
- Issue
- 7
- Pages
- 664-669
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2335358665
- Cited by
- 366
- References
- 38
- Citations by year
- 2026: 30 · 2025: 34 · 2024: 23 · 2023: 30 · 2022: 41 · 2021: 30 · 2020: 44 · 2019: 39 · 2018: 39 · 2017: 42 · 2016: 14
- FWCI
- 6.04
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Inflammatory Myopathies and Dermatomyositis
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Pharmacology › Drug-Induced Adverse Reactions
- Keywords
- statins, autoimmune myositis, HMG-CoA reductase, autoantibodies, drug-induced myopathy, adverse drug reactions
- MeSH terms
- Algorithms, Autoimmune Diseases, Glucocorticoids, Humans, Muscular Diseases, Prednisone, Muscle, Skeletal, Hydroxymethylglutaryl-CoA Reductase Inhibitors
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