Monoclonal gammopathy of undetermined significance
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A multifactorial pathogenesis model in which immune system dynamics, chronic antigenic stimulation, genetic predisposition, and genomic complexity interact within a complex ecosystem can ultimately drive disease progression and organ damage.
“These epidemiologic data suggest a multifactorial pathogenesis in which immune system dynamics, chronic antigenic stimulation, genetic predisposition, and genomic complexity interact within a complex ecosystem that can ultimately drive disease progression and organ damage.16”
From Evolution of Multiple Myeloma from a Genomic Perspective (2026) · cites this paper as [16]
Cites
Prevalence of monoclonal gammopathy of undetermined significance
Kyle, R. A., Therneau, T. M., Rajkumar, S. V., Larson, D. R., Plevak, M. F., Offord, J. R., Dispenzieri, A., Katzmann, J. A., & Melton, L. J. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa054494 · Cited by 1,423 · see citing works
Self-citationLong-Term Follow-up of Monoclonal Gammopathy of Undetermined Significance
Kyle, R. A., Larson, D. R., Therneau, T. M., Dispenzieri, A., Kumar, S., Cerhan, J. R., & Rajkumar, S. V. (2018) · New England Journal of Medicine · doi:10.1056/nejmoa1709974 · Cited by 647 · see citing works
Self-citationClonal immunoglobulin against lysolipids in the origin of myeloma
Nair, S., Branagan, A. R., Liu, J., Boddupalli, C. S., Mistry, P. K., & Dhodapkar, M. V. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1508808 · Cited by 203 · see citing works
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Evolution of Multiple Myeloma from a Genomic Perspective
Maura, F., Samur, M., & Munshi, N. (2026) · Blood · doi:10.1182/blood.2024026313 · Cited by 8 · see citing works
- Authors
- Rajkumar, S. V., & Kumar, S.
- Affiliations
- Mayo Clinic (US)
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2025-10-02
- Volume
- 393
- Issue
- 13
- Pages
- 1315-1326
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W4414780567
- Cited by
- 31
- References
- 3
- Citations by year
- 2026: 28 · 2025: 3
- FWCI
- 5.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Multiple Myeloma Research and Treatments
- Health Sciences › Medicine › Genetics › Chronic Lymphocytic Leukemia Research
- Health Sciences › Medicine › Pathology and Forensic Medicine › Lymphoma Diagnosis and Treatment
- Keywords
- monoclonal gammopathy of undetermined significance, monoclonal gammopathy, M protein, multiple myeloma, Waldenström macroglobulinemia
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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