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Responsive biomimetic hydrogel valve for microfluidics
Abstract
A biomimetic hydrogel valve capable of directional flow control in response to the local fluid environment in microfluidic channels is described. The valve consists of a pair of photopolymerized hydrogel bistrips with different pH sensitivities, and becomes activated or deactivated reversibly based on local pH as a result of volume and shape changes. When activated at pH 8, the valve mimics anatomic venous valves both functionally and structurally, allowing fluid flow in one direction under forward pressure while restricting flow in the opposite direction. At an applied pressure of 0.71 psi, the forward flow rate was 140 μL/min, compared to a backward leakage rate of 2.3 μL/min.
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Citations
Cited by
Microfluidics: Fluid physics at the nanoliter scale
Squires, T. M., & Quake, S. R. (2005) · Reviews of Modern Physics · doi:10.1103/revmodphys.77.977 · Cited by 4,379
Advances in engineering hydrogels
Zhang, Y. S., & Khademhosseini, A. (2017) · Science · doi:10.1126/science.aaf3627 · Cited by 2,908
Synthetic Molecular Motors and Mechanical Machines
Kay, E. R., Leigh, D. A., & Zerbetto, F. (2007) · Angewandte Chemie International Edition · doi:10.1002/anie.200504313 · Cited by 2,609
Synthetische molekulare Motoren und mechanische Maschinen
Kay, E. R., Leigh, D. A., & Zerbetto, F. (2007) · Angewandte Chemie · doi:10.1002/ange.200504313 · Cited by 624
Lee, Y., Song, W. J., & Sun, J.-Y. (2020) · Materials Today Physics · doi:10.1016/j.mtphys.2020.100258 · Cited by 507
Metadata
- Authors
- Yu, Q., Bauer, J. M., Moore, J. S., & Beebe, D. J.
- Venue
- Applied Physics Letters
- Publisher
- AIP Publishing
- Published
- 2001-04-23
- Volume
- 78
- Issue
- 17
- Pages
- 2589-2591
- ISSN
- 0003-6951 (ISSN-L)
- 1077-3118
- OpenAlex
- W1985718165
- Cited by
- 262
- References
- 0
- FWCI
- 6.88
- Type
- journal article
- Language
- en
- Open access
- closed
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- Yu, Q., Bauer, J. M., Moore, J. S., & Beebe, D. J. (2001). Responsive biomimetic hydrogel valve for microfluidics. Applied Physics Letters. https://doi.org/10.1063/1.1367010
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