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Cited by 181

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Single-molecule approach to dispersed kinetics and dynamic disorder: Probing conformational fluctuation and enzymatic dynamics

Sunney Xie, X.·2002·The Journal of Chemical Physics

Abstract

This article reviews our efforts in understanding dynamical fluctuations of both conformation and enzymatic reactivity in single biomolecules. The single-molecule approach is shown to be particularly powerful for studies of dispersed kinetics and dynamic disorder. New single-molecule observations have revealed conformational transitions occurring on a broad range of timescales, 100 μs–10 s, offering new clues for understanding energy landscape of proteins, as well as the structural and chemical dynamics therein.

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Metadata

Authors
Sunney Xie, X.
Venue
The Journal of Chemical Physics
Published
2002-12-22
Volume
117
Issue
24
Pages
11024-11032
ISSN
  • 0021-9606 (ISSN-L)
  • 1089-7690
OpenAlex
W2148457628
Cited by
181
References
1
FWCI
4.64
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Single-molecule approach to dispersed kinetics and dynamic disorder: Probing conformational fluctuation and enzymatic dynamics. https://app.cochat.ai/papers/10.1063/1.1521159
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Sunney Xie, X. (2002). Single-molecule approach to dispersed kinetics and dynamic disorder: Probing conformational fluctuation and enzymatic dynamics. The Journal of Chemical Physics. https://doi.org/10.1063/1.1521159

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.