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Optical observation of lipid- and polymer-shelled ultrasound microbubble contrast agents
Open accessAbstract
High-speed optical experiments demonstrate that the behavior of a polymer-shelled microbubble contrast agent in response to an acoustic pulse is qualitatively and quantitatively different from that of a lipid-shelled agent. The lipid-shelled agent expands in response to a two-cycle pulse, and at pressures approaching 1 MPa, both the shell and its contents fragment. The polymer-shelled agent remains largely intact at pressures up to 1.5 MPa and exhibits a different destruction mechanism: the polymer shell does not oscillate significantly in response to ultrasound; instead, a gas bubble is extruded and ejected through a shell defect while the shell appears to remain largely intact.
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Citations
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Taylor, R., Coulombe, S., Otanicar, T., Phelan, P., Gunawan, A., Lv, W., Rosengarten, G., Prasher, R., & Tyagi, H. (2013) · Journal of Applied Physics · doi:10.1063/1.4754271 · Cited by 759
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Metadata
- Authors
- Bloch, S. H., Wan, M., Dayton, P. A., & Ferrara, K. W.
- Venue
- Applied Physics Letters
- Publisher
- AIP Publishing
- Published
- 2004-01-26
- Volume
- 84
- Issue
- 4
- Pages
- 631-633
- ISSN
- 0003-6951 (ISSN-L)
- 1077-3118
- OpenAlex
- W2036203675
- Cited by
- 215
- References
- 0
- FWCI
- 7.32
- Type
- journal article
- Language
- en
- Open access
- green
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- Bloch, S. H., Wan, M., Dayton, P. A., & Ferrara, K. W. (2004). Optical observation of lipid- and polymer-shelled ultrasound microbubble contrast agents. Applied Physics Letters. https://doi.org/10.1063/1.1643544
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