Room-temperature atmospheric pressure plasma plume for biomedical applications
Open accessAbstract
As low-temperature nonequilibrium plasmas come to play an increasing role in biomedical applications, reliable and user-friendly sources need to be developed. These plasma sources have to meet stringent requirements such as low temperature (at or near room temperature), no risk of arcing, operation at atmospheric pressure, preferably hand-held operation, low concentration of ozone generation, etc. In this letter, we present a device that meets exactly such requirements. This device is capable of generating a cold plasma plume several centimeters in length. It exhibits low power requirements as shown by its current-voltage characteristics. Using helium as a carrier gas, very little ozone is generated and the gas temperature, as measured by emission spectroscopy, remains at room temperature even after hours of operations. The plasma plume can be touched by bare hands and can be directed manually by a user to come in contact with delicate objects and materials including skin and dental gum without causing any heating or painful sensation.
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CP generates reactive oxygen/nitrogen species (ROS/RNS) that inactivate microbes by oxidizing lipid membranes, inducing DNA strand breaks, and denaturing functional proteins.
“These highly reactive transient species mediate diverse chemical interactions, notably in microbial inactivation where they selectively target bacterial cellular components: oxidizing lipid membranes via peroxidation, inducing DNA strand breaks through radical attack, and denaturing functional proteins by amino acid modification.”
From Effect of Atmospheric Cold Plasma Treatment on the Microorganism Growth, Diversity, and Quality of Coconut Water During Refrigerator Storage (2025) · cites this paper as [5]
The passage labeled Abstract (page not provided) reports hydroxyl radicals and atomic oxygen in the plasma plume and says oxidation of membrane lipids and proteins can lead to bacterial inactivation. It does not describe DNA strand breaks, lipid peroxidation, amino-acid modification, or selective targeting of bacterial components; it also does not establish reactive nitrogen species as mediators of these effects. (LLM, conf=0.89)
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Research works printed but not linked: 2
- M. Laroussi, IEEE Trans. Plasma Sci. 30, 1409 ͑2002͒.
- E. Stoffels, in Proceedings of the Gaseous Electronics Conference, San Francisco, CA, 21-24 October 2003, p.
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Zeng, L., Gu, W., Wang, Y., Deng, W., Wang, J., & Zhang, L. (2025) · Foods · doi:10.3390/foods14152709 · Cited by 3 · see citing works
- Authors
- Laroussi, M., & Lu, X.
- Affiliations
- Old Dominion University (US)
- ORCID
- Venue
- Applied Physics Letters
- Publisher
- AIP Publishing
- Published
- 2005-09-08
- Volume
- 87
- Issue
- 11
- ISSN
- 0003-6951 (ISSN-L)
- 1077-3118
- OpenAlex
- W2045207973
- Cited by
- 637
- References
- 0
- Citations by year
- 2026: 15 · 2025: 11 · 2024: 15 · 2023: 15 · 2022: 16 · 2021: 28 · 2020: 33 · 2019: 24 · 2018: 33 · 2017: 31 · 2016: 29 · 2015: 40 · 2014: 48 · 2013: 47 · 2012: 64
- FWCI
- 14.75
- Type
- journal article
- Language
- en
- Open access
- Locations
- Applied Physics Letters (publishedVersion)
- ODU Digital Commons (Old Dominion University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Plasma Applications and Diagnostics
- Physical Sciences › Engineering › Electrical and Electronic Engineering › Plasma Diagnostics and Applications
- Physical Sciences › Physics and Astronomy › Atomic and Molecular Physics, and Optics › Vacuum and Plasma Arcs
- Keywords
- atmospheric pressure plasma, room-temperature plasma, biomedical plasma applications, plasma source design, helium carrier gas, ozone generation, current-voltage characteristics, gas temperature measurement
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