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Field-effect control of protein transport in a nanofluidic transistor circuit
Abstract
Electrostatic interactions play an important role in nanofluidic channels when the channel size is comparable to the Debye screening length. Electrostatic fields have been used to control concentration and transport of ions in nanofluidic transistors. Here, we report a transistor-reservoir-transistor circuit that can be used to turn “on” or “off” protein transport using electrostatic fields with gate voltages of ±1V. Our results suggest that global electrostatic interactions of the protein were dominant over other interactions in the nanofluidic transistor. The fabrication technique also demonstrates the feasibility of nanofluidic integrated circuits for the manipulation of biomolecules in picoliter volumes.
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Citations
Cited by
The origins and the future of microfluidics
Whitesides, G. M. (2006) · Nature · doi:10.1038/nature05058 · Cited by 9,687
Rectification of Ionic Current in a Nanofluidic Diode
Karnik, R., Duan, C., Castelino, K., Daiguji, H., & Majumdar, A. (2007) · Nano Letters · doi:10.1021/nl062806o · Cited by 553
Self-citationFu, J., Schoch, R. B., Stevens, A. L., Tannenbaum, S. R., & Han, J. (2007) · Nature Nanotechnology · doi:10.1038/nnano.2006.206 · Cited by 334
Metadata
- Authors
- Karnik, R., Castelino, K., & Majumdar, A.
- Venue
- Applied Physics Letters
- Publisher
- AIP Publishing
- Published
- 2006-03-20
- Volume
- 88
- Issue
- 12
- ISSN
- 0003-6951 (ISSN-L)
- 1077-3118
- OpenAlex
- W1964955205
- Cited by
- 200
- References
- 0
- FWCI
- 8.04
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Field-effect control of protein transport in a nanofluidic transistor circuit. https://app.cochat.ai/papers/10.1063/1.2186967
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- Karnik, R., Castelino, K., & Majumdar, A. (2006). Field-effect control of protein transport in a nanofluidic transistor circuit. Applied Physics Letters. https://doi.org/10.1063/1.2186967
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.