The DOI matches its Crossref record.
Electrocoalescence of drops synchronized by size-dependent flow in microfluidic channels
Abstract
The use of microfluidic devices to control drops of water in a carrier oil is a promising means of performing biological and chemical assays. An essential requirement for this is the controlled coalescence of pairs of drops to mix reagents together. We show that this can be accomplished through electrocoalescence of drops synchronized by size-dependent flow in microfluidic channels. Smaller drops move faster due to the Poiseuille flow, allowing pairs of surfactant-stabilized drops to be brought into contact where they are coalesced with an electric field. We apply this method to an enzyme assay to measure enzyme kinetic constants.
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Citations
Cited by
Teh, S.-Y., Lin, R., Hung, L.-H., & Lee, A. P. (2008) · Lab on a Chip · doi:10.1039/b715524g · Cited by 2,690
Seemann, R., Brinkmann, M., Pfohl, T., & Herminghaus, S. (2012) · Reports on Progress in Physics · doi:10.1088/0034-4885/75/1/016601 · Cited by 1,049
Surfactants in droplet-based microfluidics
Baret, J.-C. (2012) · Lab Chip · doi:10.1039/c1lc20582j · Cited by 649
Microdroplet-based PCR enrichment for large-scale targeted sequencing
Tewhey, R., Warner, J. B., Nakano, M., Libby, B., Medkova, M., David, P. H., Kotsopoulos, S. K., Samuels, M. L., Hutchison, J. B., Larson, J. W., et al. (2009) · Nature Biotechnology · doi:10.1038/nbt.1583 · Cited by 454
High-throughput, single-microbe genomics with strain resolution, applied to a human gut microbiome
Zheng, W., Zhao, S., Yin, Y., Zhang, H., Needham, D. M., Evans, E. D., Dai, C. L., Lu, P. J., Alm, E. J., & Weitz, D. A. (2022) · Science · doi:10.1126/science.abm1483 · Cited by 283
“We reinject each droplet into a secondmicrofluidic device (48) that uses an electric field to merge it with a second droplet containing amplification reagents (49, 50); we collect the resulting larger droplets and incubate them to amplify the DNA.”
MethodSelf-citation
Metadata
- Authors
- Ahn, K., Agresti, J., Chong, H., Marquez, M., & Weitz, D. A.
- Venue
- Applied Physics Letters
- Publisher
- AIP Publishing
- Published
- 2006-06-26
- Volume
- 88
- Issue
- 26
- ISSN
- 0003-6951 (ISSN-L)
- 1077-3118
- OpenAlex
- W1999099986
- Cited by
- 300
- References
- 0
- FWCI
- 14.87
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ahn, K., Agresti, J., Chong, H., Marquez, M., & Weitz, D. A. (2006). Electrocoalescence of drops synchronized by size-dependent flow in microfluidic channels. Applied Physics Letters. https://doi.org/10.1063/1.2218058
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
