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Sono-activated ultrasound localization microscopy
Abstract
Scanned at very high ultrasound frame rates, injectable microbubbles can be activated sequentially as isolated punctual sources of acoustic echoes. These signals can thus be localized far beyond the diffraction limit. The resolution improvement granted by Sono-Activated Ultrasound Localization Microscopy (SAULM) was demonstrated within microfluidic channels 20 times smaller than the imaging wavelength (λ = 870 μm). The width of the channels mapped with SAULM was 13 times smaller than as they appeared under conventional ultrasound imaging. Two channels separated by λ/4.5 could be distinguished. Implementing SAULM in-vivo could lead to a complete reconstruction of the vascular tree down to the smallest capillaries at several centimeter depth.
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Citations
Cited by
Switchable Fluorophores for Single-Molecule Localization Microscopy
Li, H., & Vaughan, J. C. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00767 · Cited by 319
The Emergence of Functional Ultrasound for Noninvasive Brain–Computer Interface
Zheng, H., Niu, L., Qiu, W., Liang, D., Long, X., Li, G., Liu, Z., & Meng, L. (2023) · Research · doi:10.34133/research.0200 · Cited by 27
Metadata
- Authors
- Desailly, Y., Couture, O., Fink, M., & Tanter, M.
- Venue
- Applied Physics Letters
- Publisher
- AIP Publishing
- Published
- 2013-10-21
- Volume
- 103
- Issue
- 17
- ISSN
- 0003-6951 (ISSN-L)
- 1077-3118
- OpenAlex
- W1973042235
- Cited by
- 187
- References
- 0
- FWCI
- 3.01
- Type
- journal article
- Language
- en
- Open access
- closed
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- Desailly, Y., Couture, O., Fink, M., & Tanter, M. (2013). Sono-activated ultrasound localization microscopy. Applied Physics Letters. https://doi.org/10.1063/1.4826597
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