Cytotoxicity and antiviral activities of Asplenium nidus, Phaleria macrocarpa and Eleusine indica
Abstract
Three local medicinal plants namely Asplenium nidus (langsuyar), Eleusine indica (sambau) and Phaleria macrocarpa (mahkota dewa) were screened for the cytotoxicity and antiviral activities. Six plant extracts were prepared including the aqueous and methanol extracts from A. nidus leaf and root, aqueous extract from dried whole plant of E. indica and methanol extract from P. macrocarpa fruits. Cytotoxicity screening in Vero cell line by MTT assay showed that the CC50 values ranged from 15 to 60 mg/mL thus indicating the safety of the extracts even at high concentrations. Antiviral properties of the plant extracts were determined by plaque reduction assay. The EC50 concentrations were between 3.2 to 47 mg/mL. The selectivity indices (SI = CC50/EC50) of each tested extracts ranged from 4.3 to 63.25 indicating the usefulness of the extracts as potential antiviral agents.
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Eleusine indica has antiviral properties.
“The scientific data collected show that Eleusine indica has antidiabetic, antimalarial, antibacterial, antifungal, anti-trypanosomal, antihelmintic, antioxidant, anti-inflammatory, antiurolithiasic, antiviral, phytoremediating, hepatoprotective and phytoremediating properties.”
From Review of the literature of Eleusine indica: phytochemical, toxicity, pharmacological and zootechnical studies (2021) · cites this paper as [21]
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Adoho, A. C. C., Zinsou, F. T., Olounlade, P. A., Azando, E. V. B., Hounzangbe-Adote, M. S., & Gbangboche, A. B. (2021) · Journal of Pharmacognosy and Phytochemistry · doi:10.22271/phyto.2021.v10.i3a.14060 · Cited by 19 · see citing works
“An experiment on Vero cells showed very low cytotoxicity, with CC50 between 15 and 60 mg/mL ([21]).”
BackgroundInfluential
- Authors
- Tahir, M. M., Ibrahim, N., & Yaacob, W. A.
- Affiliations
- National University of Malaysia (MY)
- ORCID
- Ibrahim, Nazlina
- Venue
- AIP Conference Proceedings
- Publisher
- AIP Publishing LLC
- Published
- 2014
- Pages
- 549-552
- ISSN
- 0094-243X (ISSN-L)
- OpenAlex
- W2025168194
- Cited by
- 10
- References
- 0
- Citations by year
- 2023: 2 · 2022: 2 · 2021: 2 · 2020: 1 · 2018: 1 · 2017: 1 · 2015: 1
- FWCI
- 4.37
- Type
- conference paper
- Language
- en
- Open access
- closed
- Locations
- AIP conference proceedings (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
- Physical Sciences › Chemistry › Organic Chemistry › Phytochemical Studies and Bioactivities
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry Medicinal Plant Applications
- Keywords
- Asplenium nidus, Phaleria macrocarpa, Eleusine indica, medicinal plants, cytotoxicity, antiviral activity, plant extracts, Vero cells, plaque reduction assay, selectivity index, CC50, EC50, traditional medicine
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