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How microplastics are transported and deposited in realistic upper airways?

Islam, Mohammad S., Rahman, Md. Mizanur, Larpruenrudee, Puchanee, Arsalanloo, Akbar, Beni, Hamidreza Mortazavy, Islam, Md. Ariful, Gu, YuanTong, Sauret, Emilie·2023·Physics of Fluids
DOI 10.1063/5.0150703
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Abstract

Microplastics are tiny plastic debris in the environment from industrial processes, various consumer items, and the breakdown of industrial waste. Recently, microplastics have been found for the first time in the airways, which increases the concern about long-term exposure and corresponding impacts on respiratory health. To date, a precise understanding of the microplastic transport to the airways is missing in the literature. Therefore, this first-ever study aims to analyze the microplastic transport and deposition within the upper lung airways. A computational fluid dynamics-discrete phase model approach is used to analyze the fluid flow and microplastic transport in airways. The sphericity concept and shape factor values are used to define the non-spherical microplastics. An accurate mesh test is performed for the computational mesh. The numerical results report that the highly asymmetric and complex morphology of the upper airway influences the flow fields and microplastic motion along with the flow rate and microplastic shape. The nasal cavity, mouth-throat, and trachea have high pressure, while a high flow velocity is observed at the area after passing the trachea. The flow rates, shape, and size of microplastics influence the overall deposition pattern. A higher flow rate leads to a lower deposition efficiency for all microplastic shapes. The nasal cavity has a high deposition rate compared to other regions. The microplastic deposition hot spot is calculated for shape and size-specific microplastic at various flow conditions. The findings of this study and more case-specific analysis will improve the knowledge of microplastic transport in airways and benefit future therapeutics development. The future study will be focused on the effect of various microplastic shapes on the human lung airways under the healthy and diseased airways conditions.

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Citations

Cites

Research works printed but not linked: 30

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Metadata

Authors
Islam, M. S., Rahman, M. M., Larpruenrudee, P., Arsalanloo, A., Beni, H. M., Islam, M. A., Gu, Y., & Sauret, E.
Affiliations
  • School of Mechanical and Mechatronic Engineering, University of Technology Sydney (UTS) 1 , 15 Broadway, Ultimo, New South Wales 2007,
  • School of Engineering, Design and Built Environment, Western Sydney University 2 , Penrith, New South Wales 2751,
  • Department of Mechanical Engineering, Faculty of Engineering, Urmia University 3 , Urmia 30200,
  • Department of Biomedical Engineering, Arsanjan Branch, Islamic Azad University 4 , Arsanjan,
  • The University of Comilla 5 , 228/ka Kuril Progoti Sarani, Vatara, Dhaka 1229,
  • School of Mechanical, Medical and Process Engineering, Faculty of Engineering, Queensland University of Technology, Brisbane, Queensland 6 4000,
ORCID
Venue
Physics of Fluids
Publisher
AIP Publishing
Published
2023-06-01
Volume
35
Issue
6
ISSN
  • 1070-6631
  • 1089-7666
DOI
10.1063/5.0150703
Cited by
49
References
1
Language
en

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