The DOI matches its Crossref record; 28 of the 29 references it cites were found in a registry or an index.
Dog exposure in infancy decreases the subsequent risk of frequent wheeze but not of atopy
Open accessAbstract
Background Influence of household pets in the development of childhood asthma or atopy has been controversial. Objective The purpose of this study was to investigate whether pet exposure in early life decreases the subsequent risk of frequent wheezing and/or allergic sensitization. Methods This was a prospective observational birth cohort study. The setting was a large health maintenance organization in Tucson, Ariz; the subjects were a population sample of 1246 newborns enrolled at birth and followed prospectively to age 13 years. The main outcome measures were as follows: time to first report of frequent wheezing (>3 episodes in the past year), skin prick test reactivity at 6 years and 11 years of age, and total serum IgE at 9 months, 6 years, and 11 years of age. Results Children living in households with > or =1 indoor dogs at birth were less likely to develop frequent wheeze than those not having indoor dogs (P =.004). This inverse association was confined to children without parental asthma (hazard ratio = 0.47; P <.001 [Cox regression]) and was not evident for children with parental asthma (hazard ratio = 0.96; P =.87). Adjustment by potential confounders did not change the results. Indoor cat exposure was not significantly associated with the risk of frequent wheezing. Neither cat exposure in early life nor dog exposure in early life was associated with skin prick test reactivity or total serum IgE at any age. Conclusion Dog exposure in early life might prevent the development of asthma-like symptoms, at least in low-risk children with no family history of asthma. Nevertheless, early pet exposure does not seem to significantly influence the development of allergic sensitization.
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“Additionally, the potential protective effects of early-life pet exposure against asthma-like symptoms appear to be closely linked to family (especially maternal) history of asthma [165,166].”
From Advance in Managing Indoor Cat Allergen Proteins: Molecular Insights, Detection, and Control (2025) · cites this paper as [165]
Citations
Cites
Development of allergen-specific T-cell memory in atopic and normal children
Prescott, S. L., Macaubas, C., Smallacombe, T. B., Holt, B. J., Sly, P. D., & Holt, P. G. (1999) · The Lancet · doi:10.1016/s0140-6736(98)05104-6 · Cited by 896
Reduced risk of hay fever and asthma among children of farmers
Ehrenstein, V., Mutius, V., Illi, Baumann, Böhm, & Kries, V. (2000) · Clinical & Experimental Allergy · doi:10.1046/j.1365-2222.2000.00801.x · Cited by 718
Braun‐Fahrländer, GASSNER, GRIZE, NEU, SENNHAUSER, VARONIER, VUILLE, Wüthrich, & THE SCARPOL TEAM (1999) · Clinical & Experimental Allergy · doi:10.1046/j.1365-2222.1999.00479.x · Cited by 660
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Austrian children living on a farm have less hay fever, asthma and allergic sensitization
Riedler, Eder, Oberfeld, & Schreuer (2000) · Clinical & Experimental Allergy · doi:10.1046/j.1365-2222.2000.00799.x · Cited by 586
Does early exposure to cat or dog protect against later allergy development?
HESSELMAR, Åberg, Åberg, Eriksson, �., & Björkstén (1999) · Clinical & Experimental Allergy · doi:10.1046/j.1365-2222.1999.00534.x · Cited by 540
Indoor allergen exposure is a risk factor for sensitization during the first three years of life
Wahn, U., Lau, S., Bergmann, R. L., Kulig, M., Forster, J., Bergmann, K., Bauer, C.-P., & Guggenmoos-Holzmann, I. (1997) · Journal of Allergy and Clinical Immunology · doi:10.1016/s0091-6749(97)80009-7 · Cited by 522
Role of microbial burden in aetiology of allergy and asthma
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Self-citationAlternaria as a Major Allergen for Asthma in Children Raised in a Desert Environment
Halonen, M. J., Stern, D. A., Wright, A. L., Taussig, L. M., & Martinez, F. D. (1997) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.155.4.9105079 · Cited by 428
Self-citationFarm environment in childhood prevents the development of allergies
Kilpeläinen, Terho, Helenius, & Koskenvuo (2000) · Clinical & Experimental Allergy · doi:10.1046/j.1365-2222.2000.00800.x · Cited by 370
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Items 101–104 of 104
Lombardi, E., Simoni, M., La Grutta, S., Viegi, G., Bisanti, L., Chellini, E., Dell’Orco, V., Migliore, E., Petronio, M. G., Pistelli, R., et al. (2010) · Pediatric Allergy and Immunology · doi:10.1111/j.1399-3038.2009.00910.x · Cited by 38
Apfelbacher, C., Frew, E., Xiang, A., Apfel, A., & Smith, H. (2016) · Journal of Asthma · doi:10.3109/02770903.2015.1099161 · Cited by 25
Childhood Environment and Atopic Conditions, with Emphasis on Asthma in a Chilean Agricultural Area
Vargas, C., Bustos, P., Diaz, P. V., Amigo, H., & Rona, R. J. (2008) · Journal of Asthma · doi:10.1080/02770900701752540 · Cited by 16
Advance in Managing Indoor Cat Allergen Proteins: Molecular Insights, Detection, and Control
Jiang, Y., Tian, X., Fu, X., Ma, B., Wang, Z., Han, B., Tao, H., Wang, J., & Wang, X. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262210913 · Cited by 3
“Additionally, the potential protective effects of early-life pet exposure against asthma-like symptoms appear to be closely linked to family (especially maternal) history of asthma [165,166].”
Metadata
- Authors
- Remes, S. T., Castro-Rodriguez, J. A., Holberg, C. J., Martinez, F. D., & Wright, A. L.
- Affiliations
- University of Arizona (US)
- ORCID
- Remes, Sami T.
- Venue
- Journal of Allergy and Clinical Immunology
- Publisher
- Elsevier BV
- Published
- 2001-10
- Volume
- 108
- Issue
- 4
- Pages
- 509-515
- ISSN
- 0091-6749 (ISSN-L)
- OpenAlex
- W2011659244
- Cited by
- 282
- References
- 29
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 2 · 2023: 1 · 2022: 2 · 2021: 5 · 2020: 2 · 2019: 5 · 2018: 7 · 2017: 5 · 2016: 7 · 2015: 10 · 2014: 7 · 2013: 6 · 2012: 9
- FWCI
- 17.17
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Allergy and Clinical Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Suomen Lääketieteen Säätiö
- National Institutes of Health (5p50hl014136-25)
- National Heart, Lung, and Blood Institute (HL-14136, R01HL056177, HL-56177)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
- Health Sciences › Medicine › Immunology and Allergy › Allergic Rhinitis and Sensitization
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Occupational exposure and asthma
- Keywords
- dog exposure, household pets, childhood asthma, atopy, allergen sensitization, serum IgE, skin prick test reactivity, indoor cats, parental asthma, early life exposure, birth cohort
- MeSH terms
- Adolescent, Animals, Animals, Domestic, Arizona, Asthma, Cats, Child, Child, Preschool, Dogs, Environment, Controlled, Environmental Exposure, Female, Humans, Hypersensitivity, Immunoglobulin E, Male, Prospective Studies, Respiratory Hypersensitivity, Respiratory Sounds, Environmental Illness
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