Randomized clinical trial of primary treatment for temporomandibular joint disk displacement without reduction and without osseous changes: A combination of NSAIDs and mouth-opening exercise versus no treatment
Abstract
Objective The effectiveness of nonsteroidal anti-inflammatory drugs (NSAIDs) and physical therapy for disk displacement without reduction is unknown. This study compared this treatment method with nontreatment controls. Methods Sixty patients with painful disk displacement without reduction and without osseous changes were randomly divided in 2 groups, consisting of NSAID and physical therapy and a nontreated control group. Both groups were observed at 2 weeks and, for those patients who did not show any improvement, again at 4 weeks. Results There was 60% improvement in the treatment group compared with 33% in the control group during the entire 4 weeks of the study. The number needed to treat for benefit was 3.75, with a 95% CI 2.103 to 65.935. Conclusions A combination of NSAID and physical therapy for 4 weeks is effective as a primary treatment of patients with disk displacement without reduction and without osseous changes.
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Most of the studies favored the use of exercises alone or as part of a general regimen to treat people with arthrogenous TMD, including disk displacements with or without reduction.
“Although the results were mixed, most of the studies favored the use of exercises alone or as part of a general regimen to treat people with arthrogenous TMD, including disk displacements with or without reduction.58,68,84 -86”
From Effectiveness of Manual Therapy and Therapeutic Exercise for Temporomandibular Disorders: Systematic Review and Meta-Analysis (2016) · cites this paper as [86]
Regarding active mouth opening, a nonsignificant effect was found between general jaw exercises and education, splint therapy, or a control group when pooling 3 studies.
“Regarding active mouth opening, a nonsignificant effect was found between general jaw exercises and education, splint therapy, or a control group when pooling 3 studies.58,61,86”
From Effectiveness of Manual Therapy and Therapeutic Exercise for Temporomandibular Disorders: Systematic Review and Meta-Analysis (2016) · cites this paper as [86]
When pooling results of studies investigating the effectiveness of exercise alone or in combination with other conservative therapies on pain intensity, there was no statistically significant difference in pain between exercise and control groups.
“When pooling the results of the studies investigating the effectiveness of exercise alone or in combination with other conservative therapies on pain intensity, 58,61,68,86 we found that there was no statistically significant difference in pain between exercise and control groups.”
From Effectiveness of Manual Therapy and Therapeutic Exercise for Temporomandibular Disorders: Systematic Review and Meta-Analysis (2016) · cites this paper as [86]
When pooling was focused on those studies including only a control group, similar results were found, although the SMD increased (SMD=1.11; 95% CI -0.73, 2.94).
“When pooling was focused on those studies including only a control group, 68,86 similar results were found, although the SMD increased (SMDϭ1.11;95% CIϭϪ0.73,2.94).”
From Effectiveness of Manual Therapy and Therapeutic Exercise for Temporomandibular Disorders: Systematic Review and Meta-Analysis (2016) · cites this paper as [86]
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Armijo-Olivo, S., Pitance, L., Singh, V., Neto, F., Thie, N., & Michelotti, A. (2016) · Physical Therapy · doi:10.2522/ptj.20140548 · Cited by 413 · see citing works
- Authors
- Yuasa, H., & Kurita, K.
- Affiliations
- Aichi Gakuin University (JP)
- ORCID
- Yuasa, Hidemichi
- Venue
- Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology
- Publisher
- Elsevier BV
- Published
- 2001-06
- Volume
- 91
- Issue
- 6
- Pages
- 671-675
- ISSN
- 1079-2104 (ISSN-L)
- OpenAlex
- W2055348340
- Cited by
- 81
- References
- 0
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2023: 3 · 2022: 4 · 2021: 1 · 2020: 8 · 2019: 2 · 2018: 2 · 2017: 4 · 2016: 4 · 2015: 6 · 2014: 6 · 2013: 3 · 2012: 3
- FWCI
- 4.99
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Health Professions › Complementary and Manual Therapy › Temporomandibular Joint Disorders
- Health Sciences › Medicine › Pharmacology › Musculoskeletal pain and rehabilitation
- Health Sciences › Dentistry › Orthodontics › Orthodontics and Dentofacial Orthopedics
- Keywords
- temporomandibular disorders, disk displacement without reduction, nonsteroidal anti-inflammatory drugs, mouth opening exercises, physiotherapy, primary treatment, treatment effectiveness, number needed to treat
- MeSH terms
- Adolescent, Adult, Age Factors, Anti-Inflammatory Agents, Non-Steroidal, Joint Dislocations, Exercise Therapy, Facial Pain, Female, Follow-Up Studies, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Prodrugs, Statistics as Topic, Thiazines, Confidence Intervals, Range of Motion, Articular, Treatment Outcome, Sample Size, Statistics, Nonparametric, Temporomandibular Joint Disc
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