Acarbose treatment of postprandial hypoglycemia in children after Nissen fundoplication
Abstract
Dumping syndrome and postprandial hypoglycemia have been reported after Nissen fundoplication. The physiopathologic mechanisms are poorly understood and a variety of therapies have failed to control the hypoglycemia in these patients. We report a series of 6 infants with postprandial hypoglycemia after Nissen fundoplication who were treated successfully with acarbose.
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Dumping syndrome has also been reported to occur after Nissen fundoplication in children and in adults.
“Dumping syndrome has also been reported to occur after Nissen fundoplication in children and in adults (8,9).”
From Dumping syndrome after esophageal, gastric or bariatric surgery: Pathophysiology, diagnosis, and management (2017) · cites this paper as [8]
Several small studies demonstrated that acarbose improved glucose tolerance, reduced GI hormone release, reduced the incidence of hypoglycemia and improved symptoms in patients with dumping syndrome.
“Several small studies demonstrated that acarbose improved glucose tolerance, reduced GI hormone release, reduced the incidence of hypoglycemia and improved symptoms in patients with dumping syndrome (Table 3) (8,34,53,58-66).”
From Dumping syndrome after esophageal, gastric or bariatric surgery: Pathophysiology, diagnosis, and management (2017) · cites this paper as [8]
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Pathophysiology, diagnosis and management of postoperative dumping syndrome
Tack, J., Arts, J., Caenepeel, P., De Wulf, D., & Bisschops, R. (2009) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2009.148 · Cited by 387 · see citing works
van Beek, A. P., Emous, M., Laville, M., & Tack, J. (2017) · Obesity Reviews · doi:10.1111/obr.12467 · Cited by 288 · see citing works
“Dumping syndrome has also been reported to occur after Nissen fundoplication in children and in adults (8,9).”
BackgroundPostoperative surveillance and detection of postprandial hypoglycemia after fundoplasty in children
Calabria, A. C., Gallagher, P. R., Simmons, R., Blinman, T., & De León, D. D. (2011) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2011.03.049 · Cited by 46 · see citing works
- Authors
- Ng, D. D., Ferry, R. J., Kelly, A., Weinzimer, S. A., Stanley, C. A., & Katz, L. E. L.
- Affiliations
- Children's Hospital of Philadelphia (US)
- Venue
- The Journal of Pediatrics
- Publisher
- Elsevier BV
- Published
- 2001-12
- Volume
- 139
- Issue
- 6
- Pages
- 877-879
- ISSN
- 0022-3476 (ISSN-L)
- OpenAlex
- W2028101270
- Cited by
- 53
- References
- 0
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 2 · 2022: 3 · 2021: 3 · 2020: 5 · 2019: 2 · 2018: 2 · 2017: 2 · 2016: 3 · 2015: 1 · 2014: 3 · 2013: 1 · 2012: 2
- FWCI
- 0.63
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Pediatrics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (F32DK009985, T32DK007314)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastroesophageal reflux and treatments
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
- Keywords
- acarbose, postprandial hypoglycemia, dumping syndrome, Nissen fundoplication, infants, gastroparesis, carbohydrate malabsorption, pediatric surgery complications
- MeSH terms
- Child, Preschool, Female, Gastroesophageal Reflux, Humans, Hypoglycemia, Hypoglycemic Agents, Infant, Male, Fundoplication, Postprandial Period, Acarbose
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