The DOI matches its Crossref record; 29 of the 31 references it cites were found in a registry or an index.
Prenatal exposure to polychlorinated biphenyls and attention at school age
Abstract
Objective To examine the relation of prenatal polychlorinated biphenyl (PCB) exposure to child performance on neuropsychological tests of attention and information processing. Study design In this prospective, longitudinal study, assessment of prenatal PCB exposure was based on umbilical cord serum and maternal serum and milk concentrations. The children were tested in their homes at age 11 years. Multiple regression was used to examine the relation of this exposure to performance on 15 neuropsychological tests after controlling for a broad range of potential confounding variables. Results Adverse effects were seen primarily in children who had not been breast fed. Among these children, prenatal PCB exposure was associated with greater impulsivity, poorer concentration, and poorer verbal, pictorial, and auditory working memory. There was no evidence of visual-spatial deficit or increased hyperactivity. Conclusions These findings are consistent with earlier reports of greater vulnerability to prenatal PCB exposure in children who were not breast fed. It is not clear whether the protection offered by breast-feeding is caused by nutrients in breast milk or better quality of intellectual stimulation often provided by breast-feeding mothers.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Reduced attention span and increased impulsivity—features reminiscent of ADHD—were reported particularly in Dutch and American cohorts (Jacobson and Jacobson, 2003).”
From Environmental endocrine disruptors at the synapse: mechanisms linking chemical exposure to cognitive and behavioral dysfunction (2026) · cites this paper as Jacobson and Jacobson, 2003
Citations
Cites
Statistical principles in experimental design.
Winer, B. J. (1962) · McGraw-Hill Book Company · doi:10.1037/11774-000 · Cited by 27,137
Applied Regression Analysis and Other Multivariable Methods
Walker, E., Kleinbaum, D. G., Kupper, L. L., & Muller, K. E. (1989) · Technometrics · doi:10.2307/1270375 · Cited by 8,538
Statistical Principles in Experimental Design
Myers, J. L., & Winer, B. J. (1964) · The American Journal of Psychology · doi:10.2307/1419292 · Cited by 8,111
A continuous performance test of brain damage
Rosvold, H. E., Mirsky, A. F., Sarason, I., Bransome, E. D., & Beck, L. H. (1956) · Journal of Consulting Psychology · doi:10.1037/h0043220 · Cited by 2,261
Memory-scanning: mental processes revealed by reaction-time experiments.
Sternberg, S. (1969) · PubMed · Cited by 1,943
Intellectual impairment in children exposed to polychlorinated biphenyls in utero
Jacobson, J. L., & Jacobson, S. W. (1996) · New England Journal of Medicine · doi:10.1056/nejm199609123351104 · Cited by 1,132
Self-citationAnalysis of the elements of attention: A neuropsychological approach
Mirsky, A. F., Anthony, B. J., Duncan, C. C., Ahearn, M. B., & Kellam, S. G. (1991) · Neuropsychology Review · doi:10.1007/bf01109051 · Cited by 874
Patandin, S., Lanting, C. I., Mulder, P. G. H., Boersma, E. R., Sauer, P. J. J., & Weisglas‐Kuperus, N. (1999) · The Journal of Pediatrics · doi:10.1016/s0022-3476(99)70369-0 · Cited by 456
Neonatal effects of transplacental exposure to PCBs and DDE
Rogan, W. J., Gladen, B. C., McKinney, J. D., Carreras, N., Hardy, P., Thullen, J. D., Tinglestad, J., & Tully, M. R. (1986) · The Journal of Pediatrics · doi:10.1016/s0022-3476(86)80397-3 · Cited by 443
The Effect of Intrauterine PCB Exposure on Visual Recognition Memory
Jacobson, S. W., Fein, G. G., Jacobson, J. L., Schwartz, P. M., & Dowler, J. K. (1985) · Child Development · doi:10.2307/1130097 · Cited by 437
Self-citation
Research works printed but not linked: 4
- Sawyer, 1978, Quantitation of polychlorinated biphenyl residues by electron capture gas-liquid chromatography, J Assoc Off Anal Chem, 61, 272
- Needham, 1981, Temperature-programmed gas chromatographic determination of PCB and PBB serum, J Assoc Off Anal Chem, 64, 1131
- Vreugdenhil HJI, Van Zanten BGA, Brocaar MP, Mulder PGH, Weisglas-Kuperus N. Prenatal PCB exposure and breast-feeding and auditory P300 latencies in 9-year-old Dutch children. Dev Med Child Neurol, in press.
- Jacobson, 1998, Preliminary evidence of working memory and attention deficits in 7-year-olds prenatally exposed to alcohol, Alcohol Clin Exp Res, 22, 61A
Cited by
Sorted by citations
Items 201–219 of 219
Comparison Between PCB Exposure and Hypothyroidism: Behavioral Development in Sprague-Dawley Rats
Toth, C. L. (2009) · OhioLink ETD Center (Ohio Library and Information Network)
Miller, M. M., & Sable, H. J. K. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-809405-1.00041-9
Sharma, N., Jamwal, S., & Bansal, P. (2017) · Springer eBooks · doi:10.1007/978-981-10-5981-0_15
Schlotz, W. (2011) · Springer eBooks · doi:10.1007/978-1-4419-1695-2_333
van den Berg, M. (2012) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.717967403.793467054
Ubiquitous environmental pollutants and neurodevelopment
Étiemble, J., & Cordier, S. (2022) · Environnement Risques Santé · doi:10.1684/ers.2021.1611
Schlotz, W. (2018) · Springer eBooks · doi:10.1007/978-3-319-33228-4_333
von Stackelberg, K. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-409548-9.11921-9
Environmental Agents and Reproductive Risk
Goetzl, L. M. (2012) · Wiley eBooks · doi:10.1002/9781119963783.ch4
Liew, Z. (2014) · eScholarship (California Digital Library)
Environmental Agents and Reproductive Risk
Goetzl, L. M., & Backley, S. (2023) · Wiley eBooks · doi:10.1002/9781119636540.ch4
Animal models of attention-deficit/hyperactivity disorder: Diversity and validity
Nehme, S. B. S., Sánchez‐Sarasúa, S., Medrano, M., Bouchatta, O., Bitar, T., Alameddine, A., Galineau, L., Brunault, P., Kerekes, N., Sánchez‐Pérez, A. M., et al. (2025) · Pharmacological Reviews · doi:10.1016/j.pharmr.2025.100108
Vermeir, G., Covaci, A., Van Larebeke, N., Schoeters, G., Nelen, V., Gudrun, K., & Viaene, M. (2021) · Figshare · doi:10.6084/m9.figshare.14129423
Vermeir, G., Covaci, A., Van Larebeke, N., Schoeters, G., Nelen, V., Gudrun, K., & Viaene, M. (2021) · Figshare · doi:10.6084/m9.figshare.14129429
Vermeir, G., Covaci, A., Van Larebeke, N., Schoeters, G., Nelen, V., Gudrun, K., & Viaene, M. (2021) · Figshare · doi:10.6084/m9.figshare.14129426
Vermeir, G., Covaci, A., Van Larebeke, N., Schoeters, G., Nelen, V., Gudrun, K., & Viaene, M. (2021) · Figshare · doi:10.6084/m9.figshare.14129432
Barrea, C., Dufour, P., Pirard, C., Charlier, C., Brévers, F., Parent, A., & Rousselle, L. (2026) · Journal of the Endocrine Society · doi:10.1210/jendso/bvag057
Bouchatta, O. (2018) · theses.fr (ABES) · doi:10.70675/5acdd85dz1833z429eza36az308928086d39
Organizational impacts of hypothyroidism on behavior
Northcutt, K. V. (2026) · Hormones and Behavior · doi:10.1016/j.yhbeh.2026.105983
Metadata
- Authors
- Jacobson, J. L., & Jacobson, S. W.
- Affiliations
- Wayne State University (US)
- Corresponding author
- Jacobson, Joseph L
- Jacobson, Sandra W
- Venue
- The Journal of Pediatrics
- Publisher
- Elsevier BV
- Published
- 2003-12
- Volume
- 143
- Issue
- 6
- Pages
- 780-788
- ISSN
- 0022-3476 (ISSN-L)
- OpenAlex
- W2054804796
- Cited by
- 219
- References
- 31
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 4 · 2023: 4 · 2022: 5 · 2021: 11 · 2020: 7 · 2019: 7 · 2018: 6 · 2017: 9 · 2016: 9 · 2015: 16 · 2014: 12 · 2013: 13 · 2012: 17
- FWCI
- 7.47
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Pediatrics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01es003256-03)
- U.S. Public Health Service (80852010)
- National Institute of Environmental Health Sciences (R01-ES05843, R01-ES03256)
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Pesticide Exposure and Toxicity
- Keywords
- polychlorinated biphenyls, prenatal exposure, attention, elementary school students, breastfeeding, umbilical cord serum, maternal serum, milk, impulsivity, working memory, information processing, neurodevelopmental effects
- MeSH terms
- Attention Deficit Disorder with Hyperactivity, Breast Feeding, Child, Environmental Pollutants, Female, Fetal Blood, Humans, Longitudinal Studies, Male, Memory Disorders, Milk, Human, Neuropsychological Tests, Polychlorinated Biphenyls, Pregnancy, Prenatal Exposure Delayed Effects, Prospective Studies, Serum
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
