Controlled delivery of levothyroxine using porous silicon as a drug nanocontainer
Abstract
Porous silicon (pSi) materials are regarded as promising drug delivery vehicles due to their biocompatibility, in vivo degradation, and resorption. We examine pSi films as a platform for the controlled delivery of levothyroxine, as a means to overcome problems with consistent dosage of this drug by oral administration. Oxidized pSi films were modified with 3-(aminopropyl)triethoxysilane (APTES), creating a surface chemistry that increased levothyroxine drug loading capacity by 50 % and sustained drug release under physiological conditions for 14 days. Release kinetics from APTES-functionalized films initially followed a zero-order release profile, which is highly desirable for drug delivery. The loading and release profiles of levothyroxine suggest that the film size required to deliver a therapeutic dose is feasible for further consideration as an implantable delivery system.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
3-(Aminopropyl) triethoxysilane was added to dramatically increase the affinity to the hydrophobic drug molecule.
“3-(Aminopropyl) triethoxysilane was added to dramatically increase the affinity to this hydrophobic drug molecule.”
From Levothyroxine: conventional and novel drug delivery formulations. (2023) · cites this paper as [269]
The porous silicon membrane height was approximately 2 μm and it bound LT4 through hydrogen bonding.
“The height of the porous silicon membrane was ∼2 µm and it bound LT4 through hydrogen bonding.”
From Levothyroxine: conventional and novel drug delivery formulations. (2023) · cites this paper as [269]
An in vitro experiment demonstrated a first-order release profile of 87% of the total contents of 21 μg in an approximately 14-day period.
“An in vitro experiment demonstrated a first-order release profile of 87% of the total contents of 21 µg in an ∼14-day period.”
From Levothyroxine: conventional and novel drug delivery formulations. (2023) · cites this paper as [269]
The citation lists haven’t been fetched yet
References 56 · Cited by 13
- Authors
- Kashanian, S., Rostami, E., Harding, F. J., McInnes, S. J. P., Al-Bataineh, S., & Voelcker, N. H.
- Affiliations
- Razi University (IR)
- Islamic Azad University, Tehran (IR)
- University of South Australia (AU)
- CARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Mawson Institute, University of South Australia, Adelaide, SA 5001, Australia.
- Corresponding author
- Kashanian, Soheila
- Voelcker, Nicolas H.
- Venue
- Australian Journal of Chemistry
- Publisher
- CSIRO Publishing
- Published
- 2015-08-31
- Volume
- 69
- Issue
- 2
- Pages
- 204-211
- ISSN
- 0004-9425 (ISSN-L)
- 1445-0038
- OpenAlex
- W2145816445
- Cited by
- 13
- References
- 56
- Citations by year
- 2025: 1 · 2024: 3 · 2023: 2 · 2022: 1 · 2019: 2 · 2018: 1 · 2016: 3
- FWCI
- 0.54
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Australian Journal of Chemistry (publishedVersion)
- Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
- Funders
- Australian Research Council
- National Health and Medical Research Council
- National Medical Research Council
- Topics
- Physical Sciences › Materials Science › Materials Chemistry › Silicon Nanostructures and Photoluminescence
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Keywords
- porous silicon, levothyroxine, controlled drug release, APTES surface modification, sustained drug release, zero-order release kinetics, drug loading capacity, implantable drug delivery, oral drug delivery
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
