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Age and stage dependency of estrogen receptor expression by lymphocyte precursors
Open accessAbstract
Sex steroids negatively regulate B lymphopoiesis in adult mice. Paradoxically, lymphocytes arise during fetal life, when estrogen levels are high and maternal lymphopoiesis is suppressed. Here we demonstrate that embryonic B lymphopoiesis was unaffected by estrogen, but sensitive to glucocorticoids. Both fetal and adult precursors contained glucocorticoid receptor transcripts, but only adult precursors expressed estrogen receptor α and β together with the androgen receptor. Fetal hematopoietic cells did not efficiently acquire functional estrogen receptors after transplantation to irradiated adult mice. Sex steroid receptors were also expressed in a stage- and developmental age-dependent fashion in human precursors. A developmental switch in responsiveness of hematopoietic cells to sex steroids may be essential for formation of the immune system.
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Cited by
Influence of Androgens on Immunity to Self and Foreign: Effects on Immunity and Cancer
Ben-Batalla, I., Vargas-Delgado, M. E., von Amsberg, G., Janning, M., & Loges, S. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01184 · Cited by 149
“Interestingly, AR are expressed also in hematopoietic stem cells and lymphoid and myeloid progenitor cells (44, 53, 54).”
BackgroundKiss, D., Ioja, E., Toth, I., Barany, Z., Jocsak, G., Bartha, T., Horvath, T., & Zsarnovszky, A. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19051440 · Cited by 18
Metadata
- Authors
- Igarashi, H., Kouro, T., Yokota, T., Comp, P. C., & Kincade, P. W.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2001-12-18
- Volume
- 98
- Issue
- 26
- Pages
- 15131-15136
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2025773873
- Cited by
- 165
- References
- 0
- FWCI
- 5.52
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Age and stage dependency of estrogen receptor expression by lymphocyte precursors. https://app.cochat.ai/papers/10.1073/pnas.011513098
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- Igarashi, H., Kouro, T., Yokota, T., Comp, P. C., & Kincade, P. W. (2001). Age and stage dependency of estrogen receptor expression by lymphocyte precursors. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.011513098
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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