The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Selective induction of neuropilin-1 by vascular endothelial growth factor (VEGF): A mechanism contributing to VEGF-induced angiogenesis
Open accessAbstract
Neuropilin (NRP) 1, previously identified as a neuronal receptor that mediates repulsive growth cone guidance, has been shown recently to function also in endothelial cells as an isoform-specific receptor for vascular endothelial growth factor (VEGF) 165 and as a coreceptor in vitro of VEGF receptor 2. However, its potential role in pathologic angiogenesis remains unknown. In the present study, we first show that VEGF selectively up-regulates NRP1 but not NRP2 via the VEGF receptor 2-dependent pathway. By NRP1 binding analysis, we showed that its induction by VEGF accompanies functional receptor expression. Endothelial proliferation stimulated by VEGF 165 was inhibited significantly by antibody perturbation of NRP1. In a murine model of VEGF-dependent angioproliferative retinopathy, intense NRP1 mRNA expression was observed in the newly formed vessels. Furthermore, selective NRP1 inhibition in this model suppressed neovascular formation substantially. These results suggest that VEGF cannot only activate endothelial cells directly but also can contribute to robust angiogenesis in vivo by a mechanism that involves up-regulation of its cognate receptor expression.
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Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis
Shweiki, D., Itin, A., Soffer, D., & Keshet, E. (1992) · Nature · doi:10.1038/359843a0 · Cited by 4,617
Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice
Shalaby, F., Rossant, J., Yamaguchi, T. P., Gertsenstein, M., Wu, X.-F., Breitman, M. L., & Schuh, A. C. (1995) · Nature · doi:10.1038/376062a0 · Cited by 3,931
Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium
Fong, G.-H., Rossant, J., Gertsenstein, M., & Breitman, M. L. (1995) · Nature · doi:10.1038/376066a0 · Cited by 2,606
Cited by
Mukouyama, Y.-S., Gerber, H.-P., Ferrara, N., Gu, C., & Anderson, D. J. (2005) · Development · doi:10.1242/dev.01675 · Cited by 266
Timmons, J. A., Jansson, E., Fischer, H., Gustafsson, T., Greenhaff, P. L., Ridden, J., Rachman, J., & Sundberg, C. J. (2005) · BMC Biology · doi:10.1186/1741-7007-3-19 · Cited by 135
Jain, P., Manuel, S. L., Khan, Z. K., Ahuja, J., Quann, K., & Wigdahl, B. (2009) · Journal of Virology · doi:10.1128/jvi.01054-09 · Cited by 87
Current concepts regarding the HTLV-1 receptor complex
Ghez, D., Lepelletier, Y., Jones, K. S., Pique, C., & Hermine, O. (2010) · Retrovirology · doi:10.1186/1742-4690-7-99 · Cited by 73
Protein kinase LKB1 promotes RAB7-mediated neuropilin-1 degradation to inhibit angiogenesis
Okon, I. S., Coughlan, K. A., Zhang, C., Moriasi, C., Ding, Y., Song, P., Zhang, W., Li, G., & Zou, M.-H. (2014) · Journal of Clinical Investigation · doi:10.1172/jci75371 · Cited by 52
Metadata
- Authors
- Oh, H., Takagi, H., Otani, A., Koyama, S., Kemmochi, S., Uemura, A., & Honda, Y.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2001-12-26
- Volume
- 99
- Issue
- 1
- Pages
- 383-388
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2049292409
- Cited by
- 161
- References
- 3
- FWCI
- 2.82
- Type
- journal article
- Language
- en
- Open access
- green
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- Oh, H., Takagi, H., Otani, A., Koyama, S., Kemmochi, S., Uemura, A., & Honda, Y. (2002). Selective induction of neuropilin-1 by vascular endothelial growth factor (VEGF): A mechanism contributing to VEGF-induced angiogenesis. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.012074399
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