The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Release of full-length 55-kDa TNF receptor 1 in exosome-like vesicles: A mechanism for generation of soluble cytokine receptors
Open accessAbstract
Soluble tumor necrosis factor receptors (TNFRs) are important modulators of TNF bioactivity. Proteolytic cleavage of the 28-kDa ectodomain of TNFR1 has been recognized as the mechanism by which soluble TNFR is shed. We now describe the release of exosome-like vesicles as a mechanism for the generation of soluble, full-length 55-kDa TNFR1. We found unexpectedly that the predominant form of soluble TNFR1 in human serum and lung epithelial lining fluid is a full-length 55-kDa protein. Furthermore, supernatants from human vascular endothelial cells contain only full-length 55-kDa TNFR1 that can be sedimented by high-speed centrifugation, floated on sucrose gradients at a density of 1.1 g/ml, and associated with vesicles that range in diameter from 20 nm to 50 nm. We conclude that the release of TNFR1 exosome-like vesicles represents a previously unrecognized mechanism by which constitutive production of soluble cytokine receptors may be regulated, independent of ectodomain cleavage by receptor sheddases.
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Cites
B lymphocytes secrete antigen-presenting vesicles.
Raposo, G., Nijman, H. W., Stoorvogel, W., Liejendekker, R., Harding, C. V., Melief, C. J., & Geuze, H. J. (1996) · The Journal of experimental medicine · doi:10.1084/jem.183.3.1161 · Cited by 3,546
Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes
Micheau, O., & Tschopp, J. (2003) · Cell · doi:10.1016/s0092-8674(03)00521-x · Cited by 2,738
Cited by
Routes and mechanisms of extracellular vesicle uptake
Mulcahy, L. A., Pink, R. C., & Carter, D. R. F. (2014) · Journal of Extracellular Vesicles · doi:10.3402/jev.v3.24641 · Cited by 2,832
Exosomes: From biogenesis and secretion to biological function
Keller, S., Sanderson, M. P., Stoeck, A., & Altevogt, P. (2006) · Immunology Letters · doi:10.1016/j.imlet.2006.09.005 · Cited by 855
Exosomes: immune properties and potential clinical implementations
Chaput, N., & Théry, C. (2011) · Seminars in Immunopathology · doi:10.1007/s00281-010-0233-9 · Cited by 560
Apoptotic Cell-Derived Extracellular Vesicles: More Than Just Debris
Caruso, S., & Poon, I. K. H. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01486 · Cited by 541
Lee, T. H., D’Asti, E., Magnus, N., Al-Nedawi, K., Meehan, B., & Rak, J. (2011) · Seminars in Immunopathology · doi:10.1007/s00281-011-0250-3 · Cited by 494
Metadata
- Authors
- Hawari, F. I., Rouhani, F. N., Cui, X., Yu, Z.-X., Buckley, C., Kaler, M., & Levine, S. J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2004-01-26
- Volume
- 101
- Issue
- 5
- Pages
- 1297-1302
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2064448614
- Cited by
- 214
- References
- 2
- FWCI
- 3.61
- Type
- journal article
- Language
- en
- Open access
- green
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- Hawari, F. I., Rouhani, F. N., Cui, X., Yu, Z.-X., Buckley, C., Kaler, M., & Levine, S. J. (2004). Release of full-length 55-kDa TNF receptor 1 in exosome-like vesicles: A mechanism for generation of soluble cytokine receptors. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0307981100
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