The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Mutations arising in the wave front of an expanding population
Open accessAbstract
The ability to infer the time and place of origin of a mutation can be very useful when reconstructing the evolutionary histories of populations and species. We use forward computer simulations of population growth, migration, and mutation in an analysis of an expanding population with a wave front that advances at a constant slow rate. A pronounced founder effect can be observed among mutations arising in this wave front where extreme population bottlenecks arise and are followed by major population growth. A fraction of mutations travel with the wave front and generate mutant populations that are on average much larger than those that remain stationary. Analysis of the diffusion of these mutants makes it possible to reconstruct migratory trajectories during population expansions, thus helping us better understand observed patterns in the evolution of species such as modern humans. Examination of some historical data supports our model.
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“According to the expansion hypothesis (19), as HGs spread over Europe, their NE introgression levels increased because of a combination of stochastic demographic and migratory processes related to gene dilution (20, 31, 39) and gene surfing (22, 23), which explain the spatial gradients of NE ancestry observed in HGs (Fig. 5).”
From Past human expansions shaped the spatial pattern of Neanderthal ancestry (2023) · cites this paper as [22]
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Cites
THE WAVE OF ADVANCE OF ADVANTAGEOUS GENES
Fisher, R. A. (1937) · Annals of Eugenics · doi:10.1111/j.1469-1809.1937.tb02153.x · Cited by 4,937
The History and Geography of Human Genes
Cavalli-Sforza, L. L., Menozzi, P., & Piazza, A. (2018) · Princeton University Press eBooks · doi:10.2307/j.ctv301gjp · Cited by 3,175
Self-citationRANDOM DISPERSAL IN THEORETICAL POPULATIONS
Skellam, J. G. (1951) · Biometrika · doi:10.1093/biomet/38.1-2.196 · Cited by 2,637
History and Geography of Human Genes
Piazza, A. (1994) · Advances in forensic haemogenetics · doi:10.1007/978-3-642-78782-9_1 · Cited by 1,639
Natural selection shaped regional mtDNA variation in humans
Mishmar, D., Ruiz‐Pesini, E., Golik, P., Macaulay, V. A., Clark, A. G., Hosseini, S., Brandon, M., Easley, K. A., Chen, E., Brown, M. D., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0136972100 · Cited by 1,040
The Neolithic Transition and the Genetics of Populations in Europe
Ammerman, A. J., & Cavalli-Sforza, L. L. (1984) · Princeton University Press eBooks · doi:10.1515/9781400853113 · Cited by 979
Self-citationThe phylogeography of Y chromosome binary haplotypes and the origins of modern human populations
Underhill, P. A., Passarino, G., Lin, A. A., Shen, P., Lahr, M. M., Foley, R., Oefner, P. J., & Cavalli-Sforza, L. L. (2001) · Annals of Human Genetics · doi:10.1046/j.1469-1809.2001.6510043.x · Cited by 782
Self-citationThe genetics of human populations
Cavalli-Sforza, L. L. (1974) · Journal of Human Evolution · doi:10.1016/0047-2484(74)90135-3 · Cited by 724
Self-citationThe application of molecular genetic approaches to the study of human evolution
Cavalli-Sforza, L. L., & Feldman, M. W. (2003) · Nature Genetics · doi:10.1038/ng1113 · Cited by 685
Self-citationParkington, J. E., & Klein, R. B. (1989) · Cited by 558
Research works printed but not linked: 2
- Rendine, S., Piazza, A. & Cavalli-Sforza, L. L. (1986) Am. Nat. 128, 762–768.
- Vlad, M. O., Moran, F., Tsuchiya, M., Cavalli-Sforza, L. L., Oefner, P. J. & Ross, J. (2002) Phys. Rev. E. 65, 061110-1–061110-17.
Cited by
Sorted by citations
Genetic Consequences of Range Expansions
Excoffier, L., Foll, M., & Petit, R. J. (2009) · Annual Review of Ecology Evolution and Systematics · doi:10.1146/annurev.ecolsys.39.110707.173414 · Cited by 1,350
Capriotti, E., Calabrese, R., & Casadio, R. (2006) · Bioinformatics · doi:10.1093/bioinformatics/btl423 · Cited by 940
THE HIDDEN SIDE OF INVASIONS: MASSIVE INTROGRESSION BY LOCAL GENES
Currat, M., Ruedi, M., Petit, R. J., & Excoffier, L. (2008) · Evolution · doi:10.1111/j.1558-5646.2008.00413.x · Cited by 816
Genetic drift at expanding frontiers promotes gene segregation
Hallatschek, O., Hersen, P., Ramanathan, S., & Nelson, D. R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0710150104 · Cited by 724
Legendre, P., & Fortin, M. (2010) · Molecular Ecology Resources · doi:10.1111/j.1755-0998.2010.02866.x · Cited by 726
Metadata
- Authors
- Edmonds, C. A., Lillie, A. S., & Cavalli-Sforza, L. L.
- Affiliations
- Stanford Medicine (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2004-01-19
- Volume
- 101
- Issue
- 4
- Pages
- 975-979
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC327127
- OpenAlex
- W2051334294
- Cited by
- 429
- References
- 12
- Citations by year
- 2026: 6 · 2025: 24 · 2024: 13 · 2023: 19 · 2022: 17 · 2021: 20 · 2020: 15 · 2019: 18 · 2018: 38 · 2017: 21 · 2016: 29 · 2015: 22 · 2014: 22 · 2013: 24 · 2012: 27
- FWCI
- 6.78
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Public Health Service (28428)
- National Institute of General Medical Sciences
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Forensic and Genetic Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic diversity and population structure
- Keywords
- mutation origin, founder effect, population growth, wavefronts, population bottleneck, migration, migratory trajectories, human evolution, population genetics, forward modeling
- MeSH terms
- Biological Evolution, Mutation
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