The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Estrogen receptor β inhibits 17β-estradiol-stimulated proliferation of the breast cancer cell line T47D
Open accessAbstract
Estrogen receptor (ER) β counteracts the activity of ERα in many systems. In agreement with this, we show in this study that induced expression of ERβ in the breast cancer cell line T47D reduces 17β-estradiol-stimulated proliferation when expression of ERβ mRNA equals that of ERα. Induction of ERβ reduces growth of exponentially proliferating cells with a concomitant decrease in components of the cell cycle associated with proliferation, namely cyclin E, Cdc25A (a key regulator of Cdk2), p45 Skp2 (a key regulator of p27 Kip1 proteolysis), and an increase in the Cdk inhibitor p27 Kip1 . We also observed a reduced Cdk2 activity. These findings suggest a possible role for ERβ in breast cancer and imply that ERβ-specific ligands may reduce proliferation of ER-positive breast cancer cells through actions on the G 1 phase cell-cycle machinery.
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Postmenopausal Hormone Replacement Therapy: Scientific Review
Nelson, H. D., Humphrey, L. L., Nygren, P., Teutsch, S. M., & Allan, J. D. (2002) · JAMA · doi:10.1001/jama.288.7.872 · Cited by 990
Estrogen and antiestrogen regulation of cell cycle progression in breast cancer cells
Doisneau-Sixou, S. F., Sergio, C. M., Carroll, J. S., Hui, R., Musgrove, E. A., & Sutherland, R. L. (2003) · Endocrine Related Cancer · doi:10.1677/erc.0.0100179 · Cited by 333
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Musgrove, E. A., & Sutherland, R. L. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2713 · Cited by 1,252
Shanle, E. K., & Xu, W. (2011) · Chemical Research in Toxicology · doi:10.1021/tx100231n · Cited by 522
The potential health effects of dietary phytoestrogens
Rietjens, I. M. C. M., Louisse, J., & Beekmann, K. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13622 · Cited by 490
Estimated Asian adult soy protein and isoflavone intakes
Messina, M., Nagata, C., & Wu, A. H. (2006) · Nutrition and Cancer · doi:10.1207/s15327914nc5501_1 · Cited by 435
Loss of ERβ expression as a common step in estrogen-dependent tumor progression
Bardin, A., Boulle, N., Lazennec, G., Vignon, F., & Pujol, P. (2004) · Endocrine-Related Cancer · doi:10.1677/erc.1.00800 · Cited by 417
Metadata
- Authors
- Ström, A., Hartman, J., Foster, J. S., Kietz, S., Wimalasena, J., & Gustafsson, J.-Å.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2004-01-26
- Volume
- 101
- Issue
- 6
- Pages
- 1566-1571
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2166766053
- Cited by
- 534
- References
- 2
- FWCI
- 14.99
- Type
- journal article
- Language
- en
- Open access
- green
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- Ström, A., Hartman, J., Foster, J. S., Kietz, S., Wimalasena, J., & Gustafsson, J.-Å. (2004). Estrogen receptor β inhibits 17β-estradiol-stimulated proliferation of the breast cancer cell line T47D. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0308319100
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