The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Dosage of Fgf8 determines whether cell survival is positively or negatively regulated in the developing forebrain
Open accessAbstract
FGF8 is known to be an important regulator of forebrain development. Here, we investigated the effects of varying the level of Fgf8 expression in the mouse forebrain. We detected two distinct responses, one that was proportionate with Fgf8 expression and another that was not. The latter response, which led to effects on cell survival, displayed a paradoxical relationship to Fgf8 dosage. Either eliminating or increasing Fgf8 expression increased apoptosis, whereas reducing Fgf8 expression had the opposite effect. To explain these counterintuitive observations, we suggest that an FGF8-dependent cell-survival pathway is negatively regulated by intracellular inhibitors produced in proportion to FGF8 concentration. Our data provide insight into the function of FGF8 in forebrain development and underscore the value of using multiple alleles and different experimental approaches to unravel the complexities of gene function in vertebrate development.
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Cites
Sprouty, an intracellular inhibitor of Ras signaling
Casci, T., Vinós, J., & Freeman, M. (1999) · Cell · doi:10.1016/s0092-8674(00)80576-0 · Cited by 467
Identification of Sef, a novel modulator of FGF signalling
Tsang, M., Friesel, R., Kudoh, T., & Dawid, I. B. (2002) · Nature Cell Biology · doi:10.1038/ncb749 · Cited by 304
Cited by
Patterning and plasticity of the cerebral cortex
Sur, M., & Rubenstein, J. L. R. (2005) · Science · doi:10.1126/science.1112070 · Cited by 677
Self-citationDecreased FGF8 signaling causes deficiency of gonadotropin-releasing hormone in humans and mice
Falardeau, J., Chung, W. C. J., Beenken, A., Raivio, T., Plummer, L., Sidis, Y., Jacobson-Dickman, E. E., Eliseenkova, A. V., Ma, J., Dwyer, A., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci34538 · Cited by 397
Different thresholds of fibroblast growth factors pattern the ventral foregut into liver and lung
Serls, A. E., Doherty, S., Parvatiyar, P., Wells, J. M., & Deutsch, G. H. (2005) · Development · doi:10.1242/dev.01570 · Cited by 316
Miraoui, H., Dwyer, A. A., Sykiotis, G. P., Plummer, L., Chung, W., Feng, B., Beenken, A., Clarke, J., Pers, T. H., Dworzynski, P., et al. (2013) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2013.04.008 · Cited by 267
Self-citationPatterning of frontal cortex subdivisions by Fgf17
Cholfin, J. A., & Rubenstein, J. L. R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0702225104 · Cited by 154
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Metadata
- Authors
- Storm, E. E., Rubenstein, J. L. R., & Martin, G. R.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2003-02-06
- Volume
- 100
- Issue
- 4
- Pages
- 1757-1762
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2074054430
- Cited by
- 181
- References
- 2
- FWCI
- 5.90
- Type
- journal article
- Language
- en
- Open access
- green
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- Storm, E. E., Rubenstein, J. L. R., & Martin, G. R. (2003). Dosage of Fgf8 determines whether cell survival is positively or negatively regulated in the developing forebrain. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0337736100
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