The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Understanding nature's design for a nanosyringe
Open accessAbstract
Synthetic and natural peptide assemblies can possess transport or conductance activity across biomembranes through the formation of nanopores. The fundamental mechanisms of membrane insertion necessary for antimicrobial or synthetic pore formation are poorly understood. We observe a lipid-assisted mechanism for passive insertion into a model membrane from molecular dynamics simulations. The assembly used in the study, a generic nanotube functionalized with hydrophilic termini, is assisted in crossing the membrane core by transleaflet lipid flips. Lipid tails occlude a purely hydrophobic nanotube. The observed insertion mechanism requirements for hydrophobic-hydrophilic matching have implications for the design of synthetic channels and antibiotics.
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Citations
Cites
Antimicrobial peptides of multicellular organisms
Zasloff, M. (2002) · Nature · doi:10.1038/415389a · Cited by 8,457
Cited by
Coarse grain models and the computer simulation of soft materials
Nielsen, S. O., Lopez, C. F., Srinivas, G., & Klein, M. L. (2004) · Journal of Physics: Condensed Matter · doi:10.1088/0953-8984/16/15/r03 · Cited by 423
Self-citationBiological and synthetic membranes: What can be learned from a coarse-grained description?
MULLER, M., KATSOV, K., & SCHICK, M. (2006) · Physics Reports · doi:10.1016/j.physrep.2006.08.003 · Cited by 320
Computational studies of membrane channels
Roux, B., & Schulten, K. (2004) · Structure · doi:10.1016/j.str.2004.06.013 · Cited by 145
Metadata
- Authors
- Lopez, C. F., Nielsen, S. O., Moore, P. B., & Klein, M. L.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2004-03-12
- Volume
- 101
- Issue
- 13
- Pages
- 4431-4434
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2148138913
- Cited by
- 293
- References
- 1
- FWCI
- 5.47
- Type
- journal article
- Language
- en
- Open access
- green
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- Lopez, C. F., Nielsen, S. O., Moore, P. B., & Klein, M. L. (2004). Understanding nature's design for a nanosyringe. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0400352101
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
