The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Antitumor activity of a homing peptide that targets tumor lymphatics and tumor cells
Open accessAbstract
LyP-1 is a peptide selected from a phage-displayed peptide library that specifically binds to tumor and endothelial cells of tumor lymphatics in certain tumors. Fluorescein-conjugated LyP-1 and a related peptide, LyP-1b, strongly accumulated in primary MDA-MB-435 breast cancer xenografts and their metastases from i.v. peptide injections, allowing visualization of orthotopic tumors in intact mice. The LyP peptide accumulation coincided with hypoxic areas in tumors. LyP-1 induced cell death in cultured human breast carcinoma cells that bind and internalize the peptide. Melanoma cells that do not bind LyP-1 were unaffected. Systemic LyP-1 peptide treatment of mice with xenografted tumors induced with the breast cancer cells inhibited tumor growth. The treated tumors contained foci of apoptotic cells and were essentially devoid of lymphatics. These results reveal an unexpected antitumor effect by the LyP-1 peptide that seems to be dependent on a proapoptotic/cytotoxic activity of the peptide. As LyP-1 affects the poorly vascularized tumor compartment, it may complement treatments directed at tumor blood vessels.
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Induction of tumor lymphangiogenesis by VEGF-C promotes breast cancer metastasis
Skobe, M., Hawighorst, T., Jackson, D. G., Prevo, R., Janes, L., Velasco, P., Riccardi, L., Alitalo, K., Claffey, K., & Detmar, M. (2001) · Nature Medicine · doi:10.1038/84643 · Cited by 1,733
LYVE-1, a New Homologue of the CD44 Glycoprotein, Is a Lymph-specific Receptor for Hyaluronan
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From Sewer to Saviour—Targeting the Lymphatic System to Promote Drug Exposure and Activity
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Tumor penetrating peptides for improved drug delivery
Ruoslahti, E. (2017) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2016.03.008 · Cited by 459
Self-citationRecent Advances in Subcellular Targeted Cancer Therapy Based on Functional Materials
Chen, W., Luo, G., & Zhang, X. (2019) · Advanced Materials · doi:10.1002/adma.201802725 · Cited by 373
Neuropilin 1: function and therapeutic potential in cancer
Chaudhary, B., Khaled, Y. S., Ammori, B. J., & Elkord, E. (2014) · Cancer Immunology, Immunotherapy · doi:10.1007/s00262-013-1500-0 · Cited by 233
Cn‐AMP1: A new promiscuous peptide with potential for microbial infections treatment
Silva, O. N., Porto, W. F., Migliolo, L., Mandal, S. M., Gomes, D. G., Holanda, H. H. S., Silva, R. S. P., Dias, S. C., Costa, M. P., Costa, C. R., et al. (2012) · Peptide Science · doi:10.1002/bip.22071 · Cited by 51
Metadata
- Authors
- Laakkonen, P., Åkerman, M. E., Biliran, H., Yang, M., Ferrer, F., Karpanen, T., Hoffman, R. M., & Ruoslahti, E.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2004-06-14
- Volume
- 101
- Issue
- 25
- Pages
- 9381-9386
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2003993864
- Cited by
- 275
- References
- 27
- FWCI
- 4.41
- Type
- journal article
- Language
- en
- Open access
- green
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- Laakkonen, P., Åkerman, M. E., Biliran, H., Yang, M., Ferrer, F., Karpanen, T., Hoffman, R. M., & Ruoslahti, E. (2004). Antitumor activity of a homing peptide that targets tumor lymphatics and tumor cells. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0403317101
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