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A role for transferrin receptor in triggering apoptosis when targeted with gambogic acid
Open accessAbstract
Transferrin receptor (TfR) has been shown to be significantly overexpressed in different types of cancers. We discovered TfR as a target for gambogic acid (GA), used in traditional Chinese medicine and a previously undiscovered link between TfR and the rapid activation of apoptosis. The binding site of GA on TfR is independent of the transferrin binding site, and it appears that GA potentially inhibits TfR internalization. Down-regulation of TfR by RNA interference decreases sensitivity to GA-induced apoptosis, further supporting TfR as the primary GA receptor. In summary, GA binding to TfR induces a unique signal leading to rapid apoptosis of tumor cells. These results suggest that GA may provide an additional approach for targeting the TfR and its use in cancer therapy.
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Crystal Structure of the Ectodomain of Human Transferrin Receptor
Lawrence, C. M., Ray, S., Babyonyshev, M., Galluser, R., Borhani, D. W., & Harrison, S. C. (1999) · Science · doi:10.1126/science.286.5440.779 · Cited by 315
Expression Profiling of Lymphocyte Plasma Membrane Proteins
Peirce, M. J., Wait, R., Begum, S., Saklatvala, J., & Cope, A. P. (2004) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m300064-mcp200 · Cited by 92
Cited by
Anti-cancer natural products isolated from chinese medicinal herbs
Tan, W., Lu, J., Huang, M., Li, Y., Chen, M., Wu, G., Gong, J., Zhong, Z., Xu, Z., Dang, Y., et al. (2011) · Chinese Medicine · doi:10.1186/1749-8546-6-27 · Cited by 396
Chemical markers for the quality control of herbal medicines: an overview
Li, S., Han, Q., Qiao, C., Song, J., Lung Cheng, C., & Xu, H. (2008) · Chinese Medicine · doi:10.1186/1749-8546-3-7 · Cited by 310
Potential of Spice-Derived Phytochemicals for Cancer Prevention
Aggarwal, B., Kunnumakkara, A., Harikumar, K., Tharakan, S., Sung, B., & Anand, P. (2008) · Planta Medica · doi:10.1055/s-2008-1074578 · Cited by 269
Metadata
- Authors
- Kasibhatla, S., Jessen, K. A., Maliartchouk, S., Wang, J. Y., English, N. M., Drewe, J., Qiu, L., Archer, S. P., Ponce, A. E., Sirisoma, N., Jiang, S., Zhang, H.-Z., Gehlsen, K. R., Cai, S. X., Green, D. R., & Tseng, B.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2005-08-15
- Volume
- 102
- Issue
- 34
- Pages
- 12095-12100
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2168386853
- Cited by
- 215
- References
- 2
- FWCI
- 8.21
- Type
- journal article
- Language
- en
- Open access
- green
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- Kasibhatla, S., Jessen, K. A., Maliartchouk, S., Wang, J. Y., English, N. M., Drewe, J., Qiu, L., Archer, S. P., Ponce, A. E., Sirisoma, N., Jiang, S., Zhang, H.-Z., Gehlsen, K. R., Cai, S. X., Green, D. R., & Tseng, B. (2005). A role for transferrin receptor in triggering apoptosis when targeted with gambogic acid. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0406731102
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