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Drosophila neuropeptide F and its receptor, NPFR1, define a signaling pathway that acutely modulates alcohol sensitivity
Open accessAbstract
Alcohol is likely to affect neurons nonselectively, and the understanding of its action in the CNS requires elucidation of underlying neuronal circuits and associated cellular processes. We have identified a Drosophila signaling system, comprising neurons expressing neuropeptide F (NPF, a homolog of mammalian neuropeptide Y) and its receptor, NPFR1, that acutely mediates sensitivity to ethanol sedation. Flies deficient in NPF/NPFR1 signaling showed decreased alcohol sensitivity, whereas those overexpressing NPF exhibited the opposite phenotype. Furthermore, controlled functional disruption of NPF or NPFR1 neurons in adults rapidly confers resistance to ethanol sedation. Finally, the NPF/NPFR1 system selectively mediates sedation by ethanol vapor but not diethyl ether, indicating that the observed NPF/NPFR1 activity reflects a specialized response to alcohol sedation rather than a general response to intoxication by sedative agents. Together, our results provide the molecular and neural basis for the strikingly similar alcohol-responsive behaviors between flies and mammals.
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Cites
Anatomy of the giant fibre pathway inDrosophila. I. Three thoracic components of the pathway
King, D. G., & Wyman, R. J. (1980) · Journal of Neurocytology · doi:10.1007/bf01205017 · Cited by 156
Cited by
A Neural Circuit Mechanism Integrating Motivational State with Memory Expression in Drosophila
Krashes, M. J., DasGupta, S., Vreede, A., White, B., Armstrong, J. D., & Waddell, S. (2009) · Cell · doi:10.1016/j.cell.2009.08.035 · Cited by 598
Motor control in a Drosophila taste circuit
Gordon, M. D., & Scott, K. (2009) · Neuron · doi:10.1016/j.neuron.2008.12.033 · Cited by 531
Drosophila neuropeptides in regulation of physiology and behavior
Nässel, D. R., & Winther, Å. M. E. (2010) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2010.04.010 · Cited by 493
Recent advances in neuropeptide signaling in Drosophila, from genes to physiology and behavior
Nässel, D. R., & Zandawala, M. (2019) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2019.02.003 · Cited by 355
Serotonin and neuropeptide F have opposite modulatory effects on fly aggression
Dierick, H. A., & Greenspan, R. J. (2007) · Nature Genetics · doi:10.1038/ng2029 · Cited by 314
Metadata
- Authors
- Wen, T., Parrish, C. A., Xu, D., Wu, Q., & Shen, P.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2005-01-27
- Volume
- 102
- Issue
- 6
- Pages
- 2141-2146
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2119334626
- Cited by
- 197
- References
- 1
- FWCI
- 3.85
- Type
- journal article
- Language
- en
- Open access
- green
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- Wen, T., Parrish, C. A., Xu, D., Wu, Q., & Shen, P. (2005). Drosophila neuropeptide F and its receptor, NPFR1, define a signaling pathway that acutely modulates alcohol sensitivity. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0406814102
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