A small-molecule inhibitor of isoprenylcysteine carboxyl methyltransferase with antitumor activity in cancer cells
Winter-Vann, Ann M., Baron, Rudi A., Wong, Waihay, dela Cruz, June, York, John D., Gooden, David M., Bergo, Martin O., Young, Stephen G. +2 more·2005·Proceedings of the National Academy of Sciences
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- BindingDB Entry 50047691: Non-Substrate Based, Small Molecule Inhibitors of the Human Isoprenylcysteine Carboxyl Methyltransferase.BindingDB · 2017 · UC San Diego
- BindingDB Entry 50045098: Development of synthetic lethality anticancer therapeutics.BindingDB · 2016 · UC San Diego
- BindingDB Entry 50021556: Spermatinamine, the first natural product inhibitor of isoprenylcysteine carboxyl methyltransferase, a new cancer target.BindingDB · 2009 · UC San Diego
- BindingDB Entry 50017349: Targeting KRAS mutant cancers by preventing signaling transduction in the MAPK pathway.BindingDB · 2023 · UC San Diego
- BindingDB Entry 50033883: Lipid and sulfur substituted prenylcysteine analogs as human Icmt inhibitors.BindingDB · 2012 · UC San Diego
- BindingDB Entry 50034481: Amide-modified prenylcysteine based Icmt inhibitors: Structure-activity relationships, kinetic analysis and cellular characterization.BindingDB · 2012 · UC San Diego
- BindingDB Entry 50017959: Amide-substituted farnesylcysteine analogs as inhibitors of human isoprenylcysteine carboxyl methyltransferase.BindingDB · 2009 · UC San Diego
- BindingDB Entry 50037603: Synthesis of desthio prenylcysteine analogs: sulfur is important for biological activity.BindingDB · 2012 · UC San Diego
- BindingDB Entry 50043100: Targeting mutant KRAS for anticancer therapeutics: a review of novel small molecule modulators.BindingDB · 2014 · UC San Diego
- BindingDB Entry 50042909: Functionalized indoleamines as potent, drug-like inhibitors of isoprenylcysteine carboxyl methyltransferase (Icmt).BindingDB · 2014 · UC San Diego
- BindingDB Entry 50042134: Ras inhibition via direct Ras binding--is there a path forward?BindingDB · 2013 · UC San Diego
- BindingDB Entry 50004134: Aplysamine 6, an alkaloidal inhibitor of Isoprenylcysteine carboxyl methyltransferase from the sponge Pseudoceratina sp.BindingDB · 2020 · UC San Diego
- BindingDB Entry 50008021: A Potent Isoprenylcysteine Carboxylmethyltransferase (ICMT) Inhibitor Improves Survival in Ras-Driven Acute Myeloid Leukemia.BindingDB · 2021 · UC San Diego
- BindingDB Entry 50032360: Amino derivatives of indole as potent inhibitors of isoprenylcysteine carboxyl methyltransferase.BindingDB · 2011 · UC San Diego
- BindingDB Entry 50033599: Discovery and SAR of methylated tetrahydropyranyl derivatives as inhibitors of isoprenylcysteine carboxyl methyltransferase (ICMT).BindingDB · 2012 · UC San Diego
- BindingDB Entry 50033282: Probing the isoprenylcysteine carboxyl methyltransferase (Icmt) binding pocket: sulfonamide modified farnesyl cysteine (SMFC) analogs as Icmt inhibitors.BindingDB · 2011 · UC San Diego
- BindingDB Entry 50041522: Quantitative structure-activity relationship (QSAR) of indoloacetamides as inhibitors of human isoprenylcysteine carboxyl methyltransferase.BindingDB · 2013 · UC San Diego