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Cited by 362Infection Control and VentilationInhalation and Respiratory Drug DeliveryIndoor Air Quality and Microbial Exposure

The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.

Inhaling to mitigate exhaled bioaerosols

Open access
Edwards, David A., Man, Jonathan C., Brand, Peter, Katstra, Jeffrey P., Sommerer, K., Stone, Howard A., Nardell, Edward, Scheuch, Gerhard·2004·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.0408159101PMC PMC536048
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Abstract

Humans commonly exhale aerosols comprised of small droplets of airway-lining fluid during normal breathing. These “exhaled bioaerosols” may carry airborne pathogens and thereby magnify the spread of certain infectious diseases, such as influenza, tuberculosis, and severe acute respiratory syndrome. We hypothesize that, by altering lung airway surface properties through an inhaled nontoxic aerosol, we might substantially diminish the number of exhaled bioaerosol droplets and thereby provide a simple means to potentially mitigate the spread of airborne infectious disease independently of the identity of the airborne pathogen or the nature of any specific therapy. We find that some normal human subjects expire many more bioaerosol particles than other individuals during quiet breathing and therefore bear the burden of production of exhaled bioaerosols. Administering nebulized isotonic saline to these “high-producer” individuals diminishes the number of exhaled bioaerosol particles expired by 72.10 ± 8.19% for up to 6 h. In vitro and in vivo experiments with saline and surfactants suggest that the mechanism of action of the nebulized saline relates to modification of the physical properties of the airway-lining fluid, notably surface tension.

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Research works printed but not linked: 8

  1. Frankova, V. (1975) Acta Virol. 19, 35–40.235195
  2. Hyslop, N. S. (1965) J. Comp. Pathol. 79, 119–126.
  3. Varma, J. K, Greene, K. D., Reller, M. E., Delong, S. M., Trottier, J., Nowicki, S. F., DiOrio, M., Koch, E. M., Bannerman, T. L., York, S. T., et al. (2003) J. Am. Med. Assoc. 260, 2709–2712.
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  5. Weibel, E. R. (1979) Bull. Eur. Physiopathol. Respir. 15, 999–1013.389332
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  7. Sukhapan, J. & Brimblecombe, P. (2002) Sci. World J. 27, 1138–1146.
  8. Spanoghe, P., Steurbaut, W., Van Eeckhout, H. & Van der Meeren, P. (2002) Meded. Rijksuniv. Gent. Fak. Landbouwkd. Toegep. Biol. Wet. 67, 129–132.12701414

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Metadata

Authors
Edwards, D. A., Man, J. C., Brand, P., Katstra, J. P., Sommerer, K., Stone, H. A., Nardell, E., & Scheuch, G.
Affiliations
Harvard University (US)
ORCID
Venue
Proceedings of the National Academy of Sciences
Publisher
National Academy of Sciences
Published
2004-12-06
Volume
101
Issue
50
Pages
17383-17388
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.0408159101
PMC
PMC536048
OpenAlex
W2143934996
Cited by
362
References
29
Citations by year
2026: 12 · 2025: 15 · 2024: 22 · 2023: 15 · 2022: 36 · 2021: 52 · 2020: 67 · 2019: 6 · 2018: 10 · 2017: 4 · 2016: 6 · 2015: 6 · 2014: 9 · 2013: 15 · 2012: 8
FWCI
4.98
Type
journal article
Language
en
Open access
Locations
  • Proceedings of the National Academy of Sciences (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Infection Control and Ventilation
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Inhalation and Respiratory Drug Delivery
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Indoor Air Quality and Microbial Exposure
Keywords
airborne infectious disease transmission, airway surface liquid, surface tension, airway lining fluid, aerosol mitigation, surfactants, influenza, tuberculosis, SARS
MeSH terms
Administration, Inhalation, Aerosols, Communicable Disease Control, Communicable Diseases, Humans, Isotonic Solutions, Nebulizers and Vaporizers, Particle Size, Sodium Chloride, Surface Tension, Viscosity, Exhalation

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