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The CYP88A cytochrome P450, ent-kaurenoic acid oxidase, catalyzes three steps of the gibberellin biosynthesis pathway
Open accessAbstract
We have shown that ent-kaurenoic acid oxidase, a member of the CYP88A subfamily of cytochrome P450 enzymes, catalyzes the three steps of the gibberellin biosynthetic pathway from ent-kaurenoic acid to GA(12). A gibberellin-responsive barley mutant, grd5, accumulates ent-kaurenoic acid in developing grains. Three independent grd5 mutants contain mutations in a gene encoding a member of the CYP88A subfamily of cytochrome P450 enzymes, defined by the maize Dwarf3 protein. Mutation of the Dwarf3 gene gives rise to a gibberellin-responsive dwarf phenotype, but the lesion in the gibberellin biosynthesis pathway has not been identified. Arabidopsis thaliana has two CYP88A genes, both of which are expressed. Yeast strains expressing cDNAs encoding each of the two Arabidopsis and the barley CYP88A enzymes catalyze the three steps of the GA biosynthesis pathway from ent-kaurenoic acid to GA(12). Sequence comparison suggests that the maize Dwarf3 locus also encodes ent-kaurenoic acid oxidase.
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Cited by
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Ro, D.-K., Paradise, E. M., Ouellet, M., Fisher, K. J., Newman, K. L., Ndungu, J. M., Ho, K. A., Eachus, R. A., Ham, T. S., Kirby, J., et al. (2006) · Nature · doi:10.1038/nature04640 · Cited by 2,805
Gibberellin biosynthesis and its regulation
Hedden, P., & Thomas, S. G. (2012) · Biochemical Journal · doi:10.1042/bj20120245 · Cited by 932
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Augustin, J. M., Kuzina, V., Andersen, S. B., & Bak, S. (2011) · Phytochemistry · doi:10.1016/j.phytochem.2011.01.015 · Cited by 799
Keeling, C. I., & Bohlmann, J. (2006) · New Phytologist · doi:10.1111/j.1469-8137.2006.01716.x · Cited by 721
A Century of Gibberellin Research
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Metadata
- Authors
- Helliwell, C. A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2001-02-06
- Volume
- 98
- Issue
- 4
- Pages
- 2065-2070
- ISSN
- 0027-8424 (ISSN-L)
- OpenAlex
- W2098217287
- Cited by
- 387
- References
- 0
- FWCI
- 4.56
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: The CYP88A cytochrome P450, ent-kaurenoic acid oxidase, catalyzes three steps of the gibberellin biosynthesis pathway. https://app.cochat.ai/papers/10.1073/pnas.041588998
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- Helliwell, C. A. (2001). The CYP88A cytochrome P450, ent-kaurenoic acid oxidase, catalyzes three steps of the gibberellin biosynthesis pathway. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.041588998
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