The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Nanohedra: Using symmetry to design self assembling protein cages, layers, crystals, and filaments
Open accessAbstract
A general strategy is described for designing proteins that self assemble into large symmetrical nanomaterials, including molecular cages, filaments, layers, and porous materials. In this strategy, one molecule of protein A, which naturally forms a self-assembling oligomer, A n , is fused rigidly to one molecule of protein B, which forms another self-assembling oligomer, B m . The result is a fusion protein, A-B, which self assembles with other identical copies of itself into a designed nanohedral particle or material, (A-B) p . The strategy is demonstrated through the design, production, and characterization of two fusion proteins: a 49-kDa protein designed to assemble into a cage approximately 15 nm across, and a 44-kDa protein designed to assemble into long filaments approximately 4 nm wide. The strategy opens a way to create a wide variety of potentially useful protein-based materials, some of which share similar features with natural biological assemblies.
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Cites
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Cited by
Self-assembling protein nanoparticles in the design of vaccines
López-Sagaseta, J., Malito, E., Rappuoli, R., & Bottomley, M. J. (2016) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2015.11.001 · Cited by 353
Chemically Controlled Protein Assembly: Techniques and Applications
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Structure of a 16-nm Cage Designed by Using Protein Oligomers
Lai, Y.-T., Cascio, D., & Yeates, T. O. (2012) · Science · doi:10.1126/science.1219351 · Cited by 278
Self-citationSelf-Assembly of Proteins into Designed Networks
Ringler, P., & Schulz, G. E. (2003) · Science · doi:10.1126/science.1088074 · Cited by 277
Proteins evolve on the edge of supramolecular self-assembly
Garcia-Seisdedos, H., Empereur-Mot, C., Elad, N., & Levy, E. D. (2017) · Nature · doi:10.1038/nature23320 · Cited by 253
Metadata
- Authors
- Padilla, J. E., Colovos, C., & Yeates, T. O.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2001-02-20
- Volume
- 98
- Issue
- 5
- Pages
- 2217-2221
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2113495611
- Cited by
- 441
- References
- 23
- FWCI
- 5.98
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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