The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
Emergent patterns of growth controlled by multicellular form and mechanics
Open accessAbstract
Spatial patterns of cellular growth generate mechanical stresses that help to push, fold, expand, and deform tissues into their specific forms. Genetic factors are thought to specify patterns of growth and other behaviors to drive morphogenesis. Here, we show that tissue form itself can feed back to regulate patterns of proliferation. Using microfabrication to control the organization of sheets of cells, we demonstrated the emergence of stable patterns of proliferative foci. Regions of concentrated growth corresponded to regions of high tractional stress generated within the sheet, as predicted by a finite-element model of multicellular mechanics and measured directly by using a micromechanical force sensor array. Inhibiting actomyosin-based tension or cadherin-mediated connections between cells disrupted the spatial pattern of proliferation. These findings demonstrate the existence of patterns of mechanical forces that originate from the contraction of cells, emerge from their multicellular organization, and result in patterns of growth. Thus, tissue form is not only a consequence but also an active regulator of tissue growth.
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Cites
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Cited by
Aragona, M., Panciera, T., Manfrin, A., Giulitti, S., Michielin, F., Elvassore, N., Dupont, S., & Piccolo, S. (2013) · Cell · doi:10.1016/j.cell.2013.07.042 · Cited by 1,651
Cellular mechanotransduction: putting all the pieces together again
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Spheroid culture as a tool for creating 3D complex tissues
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Transduction of mechanical and cytoskeletal cues by YAP and TAZ
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Mechanobiology of collective cell behaviours
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Metadata
- Authors
- Nelson, C. M., Jean, R. P., Tan, J. L., Liu, W. F., Sniadecki, N. J., Spector, A. A., & Chen, C. S.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2005-07-27
- Volume
- 102
- Issue
- 33
- Pages
- 11594-11599
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2002223490
- Cited by
- 853
- References
- 52
- FWCI
- 13.98
- Type
- journal article
- Language
- en
- Open access
- green
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- Nelson, C. M., Jean, R. P., Tan, J. L., Liu, W. F., Sniadecki, N. J., Spector, A. A., & Chen, C. S. (2005). Emergent patterns of growth controlled by multicellular form and mechanics. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0502575102
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
