The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Enhancing the anticancer properties of cardiac glycosides by neoglycorandomization
Open accessAbstract
Glycosylated natural products are reliable platforms for the development of many front-line drugs, yet our understanding of the relationship between attached sugars and biological activity is limited by the availability of convenient glycosylation methods. When a universal chemical glycosylation method that employs reducing sugars and requires no protection or activation is used, the glycorandomization of digitoxin leads to analogs that display significantly enhanced potency and tumor specificity and suggests a divergent mechanistic relationship between cardiac glycoside-induced cytotoxicity and Na + /K + -ATPase inhibition. This report highlights the remarkable advantages of glycorandomization as a powerful tool in glycobiology and drug discovery.
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Citations
Cites
Digitalis-Induced Signaling by Na+/K+-ATPase in Human Breast Cancer Cells
Kometiani, P., Liu, L., & Askari, A. (2005) · Molecular Pharmacology · doi:10.1124/mol.104.007302 · Cited by 208
Cited by
Novel therapeutic applications of cardiac glycosides
Prassas, I., & Diamandis, E. P. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2682 · Cited by 673
Natural‐Product Sugar Biosynthesis and Enzymatic Glycodiversification
Thibodeaux, C. J., Melançon, C. E., & Liu, H. (2008) · Angewandte Chemie International Edition · doi:10.1002/anie.200801204 · Cited by 444
Cardiotonic steroids on the road to anti-cancer therapy
Mijatovic, T., Van Quaquebeke, E., Delest, B., Debeir, O., Darro, F., & Kiss, R. (2007) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2007.06.002 · Cited by 317
Anticancer steroids: linking natural and semi-synthetic compounds
Salvador, J. A. R., Carvalho, J. F. S., Neves, M. A. C., Silvestre, S. M., Leitão, A. J., Silva, M. M. C., & Sá e Melo, M. L. (2013) · Nat. Prod. Rep. · doi:10.1039/c2np20082a · Cited by 276
Digitoxin as an anticancer agent with selectivity for cancer cells: possible mechanisms involved
López-Lázaro, M. (2007) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.11.8.1043 · Cited by 145
Metadata
- Authors
- Langenhan, J. M., Peters, N. R., Guzei, I. A., Hoffmann, F. M., & Thorson, J. S.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2005-08-16
- Volume
- 102
- Issue
- 35
- Pages
- 12305-12310
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1998985805
- Cited by
- 241
- References
- 1
- FWCI
- 6.75
- Type
- journal article
- Language
- en
- Open access
- green
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- Langenhan, J. M., Peters, N. R., Guzei, I. A., Hoffmann, F. M., & Thorson, J. S. (2005). Enhancing the anticancer properties of cardiac glycosides by neoglycorandomization. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0503270102
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
