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Structure of dimeric mitochondrial ATP synthase: Novel F 0 bridging features and the structural basis of mitochondrial cristae biogenesis
Open accessAbstract
The F 1 F 0 –ATP synthase exists as a dimer in mitochondria, where it is essential for the biogenesis of the inner membrane cristae. How two ATP synthase complexes dimerize to promote cristae formation is unknown. Here we resolved the structure of the dimeric F 1 F 0 ATP synthase complex isolated from bovine heart mitochondria by transmission electron microscopy. The structure of the ATP synthase dimer has an overall conic appearance that is consistent with the proposed role of the dimeric enzyme in mitochondrial cristae biogenesis. The ATP synthase dimer interface is formed by contacts on both the F 0 and F 1 domains. A cross-bridging protein density was resolved which connects the two F 0 domains on the intermembrane space side of the membrane. On the matrix side of the complex, the two F 1 moieties are connected by a protein bridge, which is attributable to the IF 1 inhibitor protein.
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Cited by
Functions and dysfunctions of mitochondrial dynamics
Detmer, S. A., & Chan, D. C. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2275 · Cited by 1,369
Cogliati, S., Frezza, C., Soriano, M. E., Varanita, T., Quintana-Cabrera, R., Corrado, M., Cipolat, S., Costa, V., Casarin, A., Gomes, L. C., et al. (2013) · Cell · doi:10.1016/j.cell.2013.08.032 · Cited by 1,265
Bonora, M., Wieckowski, M. R., Chinopoulos, C., Kepp, O., Kroemer, G., Galluzzi, L., & Pinton, P. (2015) · Oncogene · doi:10.1038/onc.2014.96 · Cited by 330
Giorgio, V., Bisetto, E., Soriano, M. E., Dabbeni-Sala, F., Basso, E., Petronilli, V., Forte, M. A., Bernardi, P., & Lippe, G. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.020115 · Cited by 305
Carraro, M., Carrer, A., Urbani, A., & Bernardi, P. (2020) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2020.05.014 · Cited by 71
Metadata
- Authors
- Minauro-Sanmiguel, F., Wilkens, S., & García, J. J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2005-08-16
- Volume
- 102
- Issue
- 35
- Pages
- 12356-12358
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2079980765
- Cited by
- 186
- References
- 0
- FWCI
- 5.99
- Type
- journal article
- Language
- en
- Open access
- green
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- Minauro-Sanmiguel, F., Wilkens, S., & García, J. J. (2005). Structure of dimeric mitochondrial ATP synthase: Novel F 0 bridging features and the structural basis of mitochondrial cristae biogenesis. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0503893102
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