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Prestressed F-actin networks cross-linked by hinged filamins replicate mechanical properties of cells
Abstract
We show that actin filaments, shortened to physiological lengths by gelsolin and cross-linked with recombinant human filamins (FLNs), exhibit dynamic elastic properties similar to those reported for live cells. To achieve elasticity values of comparable magnitude to those of cells, the in vitro network must be subjected to external prestress, which directly controls network elasticity. A molecular requirement for the strain-related behavior at physiological conditionsis a flexible hinge found in FLNa and some FLNb molecules. Basic physical properties of the in vitro filamin–F-actin network replicate the essential mechanical properties of living cells. This physical behavior could accommodate passive deformation and internal organelle trafficking at low strains yet resist externally or internally generated high shear forces.
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Citations
Cited by
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Murrell, M., Oakes, P. W., Lenz, M., & Gardel, M. L. (2015) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm4012 · Cited by 687
Self-citationMechanical regulation of bone remodeling
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Metadata
- Authors
- Gardel, M. L., Nakamura, F., Hartwig, J. H., Crocker, J. C., Stossel, T. P., & Weitz, D. A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2006-01-30
- Volume
- 103
- Issue
- 6
- Pages
- 1762-1767
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2033465506
- Cited by
- 412
- References
- 0
- FWCI
- 12.48
- Type
- journal article
- Language
- en
- Open access
- closed
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- Gardel, M. L., Nakamura, F., Hartwig, J. H., Crocker, J. C., Stossel, T. P., & Weitz, D. A. (2006). Prestressed F-actin networks cross-linked by hinged filamins replicate mechanical properties of cells. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0504777103
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