The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Cleavage of the papillomavirus minor capsid protein, L2, at a furin consensus site is necessary for infection
Open accessAbstract
Papillomaviruses (PV) comprise a large family of nonenveloped DNA viruses that include the oncogenic PV types that are the causative agents of human cervical cancer. As is true of many animal DNA viruses, PV are taken into the cell by endocytosis and must escape from the endosomal compartment to the cytoplasm to initiate infection. Here we show that this step depends on the site-specific enzymatic cleavage of the PV minor virion protein L2 at a consensus furin recognition site. Cleavage by furin, a cell-encoded proprotein convertase, is known to be required for endosome escape by many bacterial toxins. However, to our knowledge, furin has not been previously implicated in the viral entry process. This step is potentially a target for PV inhibition.
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Citations
Cites
Classification of papillomaviruses
de Villiers, E.-M., Fauquet, C., Broker, T. R., Bernard, H.-U., & zur Hausen, H. (2004) · Virology · doi:10.1016/j.virol.2004.03.033 · Cited by 3,193
Furin at the cutting edge: From protein traffic to embryogenesis and disease
Thomas, G. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm934 · Cited by 1,216
Endosomal Proteolysis of the Ebola Virus Glycoprotein Is Necessary for Infection
Chandran, K., Sullivan, N. J., Felbor, U., Whelan, S. P., & Cunningham, J. M. (2005) · Science · doi:10.1126/science.1110656 · Cited by 826
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Prediction of proprotein convertase cleavage sites
Duckert, P., Brunak, S., & Blom, N. (2004) · Protein Engineering, Design and Selection · doi:10.1093/protein/gzh013 · Cited by 583
Efficient Intracellular Assembly of Papillomaviral Vectors
Buck, C. B., Pastrana, D. V., Lowy, D. R., & Schiller, J. T. (2004) · Journal of Virology · doi:10.1128/jvi.78.2.751-757.2004 · Cited by 489
Self-citationBi-cycling the furin pathway: from TGN localization to pathogen activation and embryogenesis
Molloy, S. S., Anderson, E. D., Jean, F., & Thomas, G. (1999) · Trends in Cell Biology · doi:10.1016/s0962-8924(98)01382-8 · Cited by 429
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Endolysosomal proteolysis and its regulation
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Cited by
The Biology and Life-Cycle of Human Papillomaviruses
Doorbar, J., Quint, W., Banks, L., Bravo, I. G., Stoler, M., Broker, T. R., & Stanley, M. A. (2012) · Vaccine · doi:10.1016/j.vaccine.2012.06.083 · Cited by 1,528
Millet, J. K., & Whittaker, G. R. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1407087111 · Cited by 698
Roberts, J. N., Buck, C. B., Thompson, C. D., Kines, R., Bernardo, M., Choyke, P. L., Lowy, D. R., & Schiller, J. T. (2007) · Nature Medicine · doi:10.1038/nm1598 · Cited by 503
Self-citationSchelhaas, M., Shah, B., Holzer, M., Blattmann, P., Kühling, L., Day, P. M., Schiller, J. T., & Helenius, A. (2012) · PLoS Pathogens · doi:10.1371/journal.ppat.1002657 · Cited by 295
Self-citationIntracellular transport of recombinant adeno-associated virus vectors
Nonnenmacher, M., & Weber, T. (2012) · Gene Therapy · doi:10.1038/gt.2012.6 · Cited by 258
Metadata
- Authors
- Richards, R. M., Lowy, D. R., Schiller, J. T., & Day, P. M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2006-01-23
- Volume
- 103
- Issue
- 5
- Pages
- 1522-1527
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2167294127
- Cited by
- 375
- References
- 37
- FWCI
- 10.85
- Type
- journal article
- Language
- en
- Open access
- green
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- Richards, R. M., Lowy, D. R., Schiller, J. T., & Day, P. M. (2006). Cleavage of the papillomavirus minor capsid protein, L2, at a furin consensus site is necessary for infection. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0508815103
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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