The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Role of β-arrestin 1 in the metastatic progression of colorectal cancer
Open accessAbstract
G protein-coupled receptor ligand-dependent transactivation of growth factor receptors has been implicated in human cancer cell proliferation, migration, and cell survival. For example, prostaglandin E 2 (PGE 2 )-induced transactivation of the EGF receptor (EGFR) in colorectal carcinoma cells is mediated by means of a c-Src-dependent mechanism and regulates cell proliferation and migration. Recent evidence indicates that β-arrestin 1 may act as an important mediator in G protein-coupled receptor-induced activation of c-Src. Whether β-arrestin 1 serves a functional role in these events is, however, unknown. We investigated the effects of PGE 2 on colorectal cancer cells expressing WT and mutant β-arrestin 1. Here we report that PGE 2 induces the association of a prostaglandin E receptor 4/β-arrestin 1/c-Src signaling complex resulting in the transactivation of the EGFR and downstream Akt (PKB) signaling. The interaction of β-arrestin 1 and c-Src is critical for the regulation of colorectal carcinoma cell migration in vitro as well as metastatic spread of disease to the liver in vivo . These results show that the prostaglandin E/β-arrestin 1/c-Src signaling complex is a crucial step in PGE 2 -mediated transactivation of the EGFR and may play a pivotal role in tumor metastasis. Furthermore, our data implicate a functional role for β-arrestin 1 as a mediator of cellular migration and metastasis.
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Tsujii, M., Kawano, S., & DuBois, R. N. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.7.3336 · Cited by 1,398
Self-citationProstanoid Receptors: Subtypes and Signaling
Breyer, R. M., Bagdassarian, C. K., Myers, S. A., & Breyer, M. D. (2001) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.41.1.661 · Cited by 1,011
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Hara, M. R., Kovacs, J. J., Whalen, E. J., Rajagopal, S., Strachan, R. T., Grant, W., Towers, A. J., Williams, B., Lam, C. M., Xiao, K., et al. (2011) · Nature · doi:10.1038/nature10368 · Cited by 420
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Metadata
- Authors
- Buchanan, F. G., Gorden, D. L., Matta, P., Shi, Q., Matrisian, L. M., & DuBois, R. N.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2006-01-23
- Volume
- 103
- Issue
- 5
- Pages
- 1492-1497
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2138341116
- Cited by
- 267
- References
- 2
- FWCI
- 7.00
- Type
- journal article
- Language
- en
- Open access
- green
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- Buchanan, F. G., Gorden, D. L., Matta, P., Shi, Q., Matrisian, L. M., & DuBois, R. N. (2006). Role of β-arrestin 1 in the metastatic progression of colorectal cancer. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0510562103
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