The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Voltage-gated ion channels in the axon initial segment of human cortical pyramidal cells and their relationship with chandelier cells
Open accessAbstract
The axon initial segment (AIS) of pyramidal cells is a critical region for the generation of action potentials and for the control of pyramidal cell activity. Here we show that Na + and K + voltage-gated channels, together with other molecules involved in the localization of ion channels, are distributed asymmetrically in the AIS of pyramidal cells situated in the human temporal neocortex. There is a high density of Na + channels distributed along the length of the AIS together with the associated proteins spectrin βIV and ankyrin G. In contrast, Kv1.2 channels are associated with the adhesion molecule Caspr2, and they are mostly localized to the distal region of the AIS. In general, the distal region of the AIS is targeted by the GABAergic axon terminals of chandelier cells, whereas the proximal region is innervated, mostly by other types of GABAergic interneurons. We suggest that this molecular segregation and the consequent regional specialization of the GABAergic input to the AIS of pyramidal cells may have important functional implications for the control of pyramidal cell activity.
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Cites
Cortical inhibitory neurons and schizophrenia
Lewis, D. A., Hashimoto, T., & Volk, D. W. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1648 · Cited by 2,297
Synchronization of neuronal activity in hippocampus by individual GABAergic interneurons
Cobb, S. R., Buhl, E. H., Halasy, K., Paulsen, O., & Somogyi, P. (1995) · Nature · doi:10.1038/378075a0 · Cited by 1,498
Brain-state- and cell-type-specific firing of hippocampal interneurons in vivo
Klausberger, T., Magill, P. J., Márton, L. F., Roberts, J. D. B., Cobden, P. M., Buzsáki, G., & Somogyi, P. (2003) · Nature · doi:10.1038/nature01374 · Cited by 1,345
Defined types of cortical interneurone structure space and spike timing in the hippocampus
Somogyi, P., & Klausberger, T. (2005) · The Journal of Physiology · doi:10.1113/jphysiol.2004.078915 · Cited by 927
Klausberger, T., Márton, L. F., Baude, A., Roberts, J. D. B., Magill, P. J., & Somogyi, P. (2004) · Nature Neuroscience · doi:10.1038/nn1159 · Cited by 393
Dependence of nodal sodium channel clustering on paranodal axoglial contact in the developing CNS
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Lighting the chandelier: new vistas for axo-axonic cells
Howard, A., Tamas, G., & Soltesz, I. (2005) · Trends in Neurosciences · doi:10.1016/j.tins.2005.04.004 · Cited by 167
Cited by
Peñagarikano, O., Abrahams, B. S., Herman, E. I., Winden, K. D., Gdalyahu, A., Dong, H., Sonnenblick, L. I., Gruver, R., Almajano, J., Bragin, A., et al. (2011) · Cell · doi:10.1016/j.cell.2011.08.040 · Cited by 1,075
Ogiwara, I., Miyamoto, H., Morita, N., Atapour, N., Mazaki, E., Inoue, I., Takeuchi, T., Itohara, S., Yanagawa, Y., Obata, K., et al. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.5270-06.2007 · Cited by 879
Action potential generation requires a high sodium channel density in the axon initial segment
Kole, M. H. P., Ilschner, S. U., Kampa, B. M., Williams, S. R., Ruben, P. C., & Stuart, G. J. (2008) · Nature Neuroscience · doi:10.1038/nn2040 · Cited by 703
Distinct contributions of Nav1.6 and Nav1.2 in action potential initiation and backpropagation
Hu, W., Tian, C., Li, T., Yang, M., Hou, H., & Shu, Y. (2009) · Nature Neuroscience · doi:10.1038/nn.2359 · Cited by 706
Signal processing in the axon initial segment
Kole, M. H. P., & Stuart, G. J. (2012) · Neuron · doi:10.1016/j.neuron.2012.01.007 · Cited by 463
Metadata
- Authors
- Inda, M. C., DeFelipe, J., & Muñoz, A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2006-02-10
- Volume
- 103
- Issue
- 8
- Pages
- 2920-2925
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2024297133
- Cited by
- 185
- References
- 7
- FWCI
- 4.17
- Type
- journal article
- Language
- en
- Open access
- green
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- Inda, M. C., DeFelipe, J., & Muñoz, A. (2006). Voltage-gated ion channels in the axon initial segment of human cortical pyramidal cells and their relationship with chandelier cells. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0511197103
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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