The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Gene–environment interaction modulated by allelic heterogeneity in inflammatory diseases
Open accessAbstract
CARD15 is a major susceptibility gene for a frequent multifactorial chronic inflammatory bowel disorder, Crohn disease (CD). By using NF-κB activation assays, the cytosolic CARD15 was shown to efficiently detect bacterial peptidoglycan (PGN), reminiscent of the PGN recognition protein surveillance mechanism in Drosophila . The 3 CD-associated variants and 13 additional variants carried by CD patients demonstrated impaired PGN-dependent response revealing null, hypomorphic, or dominant-negative properties. Quantitative parametrization of this response, computed from the patients' CARD15 genotypes, was predictive of several variable CD manifestations. In contrast, CARD15 alleles associated with Blau's syndrome promoted PGN-independent NF-κB activation, an observation that accounts for the minimal microbial input in the etiology of this dominant, monogenic inflammatory disorder affecting solely aseptic sites.
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Fadok, V. A., Bratton, D. L., Konowal, A., Freed, P. W., Westcott, J. Y., & Henson, P. M. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1112 · Cited by 3,166
Cited by
NOD-LRR PROTEINS: Role in Host-Microbial Interactions and Inflammatory Disease
Inohara, N., Chamaillard, M., McDonald, C., & Nuñez, G. (2005) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.74.082803.133347 · Cited by 991
Self-citationNOD1 and NOD2: Signaling, Host Defense, and Inflammatory Disease
Caruso, R., Warner, N., Inohara, N., & Núñez, G. (2014) · Immunity · doi:10.1016/j.immuni.2014.12.010 · Cited by 830
NOD-Like Receptors: Role in Innate Immunity and Inflammatory Disease
Chen, G., Shaw, M. H., Kim, Y.-G., & Nuñez, G. (2009) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev.pathol.4.110807.092239 · Cited by 772
National Institute of Diabetes and Digestive Kidney Diseases Inflammatory Bowel Disease Genetics Consortium (NIDDK IBDGC), Rivas, M. A., United Kingdom Inflammatory Bowel Disease Genetics Consortium, International Inflammatory Bowel Disease Genetics Consortium, Beaudoin, M., Gardet, A., Stevens, C., Sharma, Y., Zhang, C. K., Boucher, G., et al. (2011) · Nature Genetics · doi:10.1038/ng.952 · Cited by 771
Peptidoglycan Molecular Requirements Allowing Detection by Nod1 and Nod2
Girardin, S. E., Travassos, L. H., Hervé, M., Blanot, D., Boneca, I. G., Philpott, D. J., Sansonetti, P. J., & Mengin-Lecreulx, D. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m307198200 · Cited by 686
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Metadata
- Authors
- Chamaillard, M., Philpott, D., Girardin, S. E., Zouali, H., Lesage, S., Chareyre, F., Bui, T. H., Giovannini, M., Zaehringer, U., Penard-Lacronique, V., Sansonetti, P. J., Hugot, J.-P., & Thomas, G.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2003-03-07
- Volume
- 100
- Issue
- 6
- Pages
- 3455-3460
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2003784229
- Cited by
- 309
- References
- 1
- FWCI
- 16.91
- Type
- journal article
- Language
- en
- Open access
- green
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- Chamaillard, M., Philpott, D., Girardin, S. E., Zouali, H., Lesage, S., Chareyre, F., Bui, T. H., Giovannini, M., Zaehringer, U., Penard-Lacronique, V., Sansonetti, P. J., Hugot, J.-P., & Thomas, G. (2003). Gene–environment interaction modulated by allelic heterogeneity in inflammatory diseases. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0530276100
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