The DOI matches its Crossref record.
The molecular basis of vernalization: The central role of FLOWERING LOCUS C (FLC)
Open accessAbstract
In Arabidopsis, the MADS-box protein encoded by FLOWERING LOCUS C (FLC) is a repressor of flowering. Vernalization, which promotes flowering in the late-flowering ecotypes and many late-flowering mutants, decreases the level of FLC transcript and protein in the plant. This vernalization-induced reduction in FLC transcript levels is mitotically stable and occurs in all tissues. FLC activity is restored in each generation, as is the requirement of a low-temperature exposure for the promotion of flowering. The level of FLC determines the extent of the vernalization response in the promotion of flowering, and there is a quantitative relationship between the duration of cold treatment and the extent of down-regulation of FLC activity. We conclude that FLC is the central regulator of the induction of flowering by vernalization. Other vernalization-responsive late-flowering mutants, which are disrupted in genes that encode regulators of FLC, are late-flowering as a consequence of their elevated levels of FLC.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Jaenisch, R., & Bird, A. (2003) · Nature Genetics · doi:10.1038/ng1089 · Cited by 6,325
Becker, A. (2003) · Molecular Phylogenetics and Evolution · doi:10.1016/s1055-7903(03)00207-0 · Cited by 990
A Repressor Complex Governs the Integration of Flowering Signals in Arabidopsis
Li, D., Liu, C., Shen, L., Wu, Y., Chen, H., Robertson, M., Helliwell, C. A., Ito, T., Meyerowitz, E., & Yu, H. (2008) · Developmental Cell · doi:10.1016/j.devcel.2008.05.002 · Cited by 522
The RNA-binding protein FCA is an abscisic acid receptor
Razem, F. A., El-Kereamy, A., Abrams, S. R., & Hill, R. D. (2006) · Nature · doi:10.1038/nature04373 · Cited by 375
RetractedFLOWERING LOCUS C (FLC) regulates development pathways throughout the life cycle of Arabidopsis
Deng, W., Ying, H., Helliwell, C. A., Taylor, J. M., Peacock, W. J., & Dennis, E. S. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1103175108 · Cited by 375
Metadata
- Authors
- Sheldon, C. C.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2000-03-14
- Volume
- 97
- Issue
- 7
- Pages
- 3753-3758
- ISSN
- 0027-8424 (ISSN-L)
- OpenAlex
- W1967192654
- Cited by
- 602
- References
- 0
- FWCI
- 44.67
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: The molecular basis of vernalization: The central role of FLOWERING LOCUS C (FLC). https://app.cochat.ai/papers/10.1073/pnas.060023597
- The paper
- Sheldon, C. C. (2000). The molecular basis of vernalization: The central role of FLOWERING LOCUS C (FLC). Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.060023597
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
