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Real-time metabolic imaging
Open accessAbstract
The endogenous substance pyruvate is of major importance to maintain energy homeostasis in the cells and provides a window to several important metabolic processes essential to cell survival. Cell viability is therefore reflected in the metabolism of pyruvate. NMR spectroscopy has until now been the only noninvasive method to gain insight into the fate of pyruvate in the body, but the low NMR sensitivity even at high field strength has only allowed information about steady-state conditions. The medically relevant information about the distribution, localization, and metabolic rate of the substance during the first minute after the injection has not been obtainable. Use of a hyperpolarization technique has enabled 10–15% polarization of 13 C 1 in up to a 0.3 M pyruvate solution. i.v. injection of the solution into rats and pigs allows imaging of the distribution of pyruvate and mapping of its major metabolites lactate and alanine within a time frame of ≈10 s. Real-time molecular imaging with MRI has become a reality.
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Cited by
Yang, C., Ko, B., Hensley, C. T., Jiang, L., Wasti, A. T., Kim, J., Sudderth, J., Calvaruso, M. A., Lumata, L., Mitsche, M., et al. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.09.025 · Cited by 679
Kurhanewicz, J., Vigneron, D. B., Brindle, K., Chekmenev, E. Y., Comment, A., Cunningham, C. H., DeBerardinis, R. J., Green, G. G., Leach, M. O., Rajan, S. S., et al. (2011) · Neoplasia · doi:10.1593/neo.101102 · Cited by 681
A review of imaging techniques for systems biology
Kherlopian, A. R., Song, T., Duan, Q., Neimark, M. A., Po, M. J., Gohagan, J. K., & Laine, A. F. (2008) · BMC Systems Biology · doi:10.1186/1752-0509-2-74 · Cited by 310
ParaHydrogen Induced Polarization of 13C carboxylate resonance in acetate and pyruvate
Reineri, F., Boi, T., & Aime, S. (2015) · Nature Communications · doi:10.1038/ncomms6858 · Cited by 296
Rajeshkumar, N. V., Dutta, P., Yabuuchi, S., de Wilde, R. F., Martinez, G. V., Le, A., Kamphorst, J. J., Rabinowitz, J. D., Jain, S. K., Hidalgo, M., et al. (2015) · Cancer Research · doi:10.1158/0008-5472.can-15-0108 · Cited by 158
“The recently discovered hyperpolarized MRI using DNP (dynamic nuclear polarization) technology has the potential of providing real-time images of metabolic processes in tumors at unprecedented levels of sensitivity for monitoring therapy responses (40-43).”
Metadata
- Authors
- Golman, K., in ‘t Zandt, R., & Thaning, M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2006-07-25
- Volume
- 103
- Issue
- 30
- Pages
- 11270-11275
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1986757721
- Cited by
- 659
- References
- 0
- FWCI
- 12.57
- Type
- journal article
- Language
- en
- Open access
- green
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