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Cited by 329

The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.

Ecological and immunological determinants of dengue epidemics

Open access
Wearing, Helen J., Rohani, Pejman·2006·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.0602960103
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Abstract

The management of infectious diseases is an increasingly important public health issue, the effective implementation of which is often complicated by difficulties in teasing apart the relative roles of extrinsic and intrinsic factors influencing transmission. Dengue, a vector-borne strain polymorphic disease, is one such infection where transmission dynamics are affected by environmental variables as well as immune-mediated serotype interactions. To understand how alternative hypotheses concerning dengue infection and transmission may explain observed multiannual cycles in disease incidence, we adopt a theoretical approach that combines both ecological and immunological mechanisms. We demonstrate that, contrary to perceived wisdom, patterns generated solely by antibody-dependent enhancement or heterogeneity in virus virulence are not consistent with serotype-specific notification data in important ways. Furthermore, to generate epidemics with the characteristic signatures observed in data, we find that a combination of seasonal variation in vector demography and, crucially, a short-lived period of cross-immunity is sufficient. We then show how understanding the persistence and eradication of dengue serotypes critically depends on the alternative assumed mechanisms.

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Metadata

Authors
Wearing, H. J., & Rohani, P.
Venue
Proceedings of the National Academy of Sciences
Publisher
Proceedings of the National Academy of Sciences
Published
2006-08
Volume
103
Issue
31
Pages
11802-11807
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.0602960103
OpenAlex
W2065211178
Cited by
329
References
37
FWCI
17.40
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Ecological and immunological determinants of dengue epidemics. https://app.cochat.ai/papers/10.1073/pnas.0602960103
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Wearing, H. J., & Rohani, P. (2006). Ecological and immunological determinants of dengue epidemics. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0602960103

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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