Cited by 356Atherosclerosis and Cardiovascular DiseasesCardiac Imaging and DiagnosticsNanoparticle-Based Drug Delivery

The DOI matches its Crossref record; 34 of the 35 references it cites were found in a registry or an index.

Detecting and assessing macrophages in vivo to evaluate atherosclerosis noninvasively using molecular MRI

Open access

Amirbekian, Vardan, Lipinski, Michael J., Briley-Saebo, Karen C., Amirbekian, Smbat, Aguinaldo, Juan Gilberto S., Weinreb, David B., Vucic, Esad, Frias, Juan C., Hyafil, Fabien, Mani, Venkatesh, Fisher, Edward A., Fayad, Zahi A.·2007·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.0606281104PMC PMC1766334

Open this paper in CoChat — free account

Abstract

We investigated the ability of targeted immunomicelles to detect and assess macrophages in atherosclerotic plaque using MRI in vivo . There is a large clinical need for a noninvasive tool to assess atherosclerosis from a molecular and cellular standpoint. Macrophages play a central role in atherosclerosis and are associated with plaques vulnerable to rupture. Therefore, macrophage scavenger receptor (MSR) was chosen as a target for molecular MRI. MSR-targeted immunomicelles, micelles, and gadolinium–diethyltriaminepentaacetic acid (DTPA) were tested in ApoE−/− and WT mice by using in vivo MRI. Confocal laser-scanning microscopy colocalization, macrophage immunostaining and MRI correlation, competitive inhibition, and various other analyses were performed. In vivo MRI revealed that at 24 h postinjection, immunomicelles provided a 79% increase in signal intensity of atherosclerotic aortas in ApoE−/− mice compared with only 34% using untargeted micelles and no enhancement using gadolinium–DTPA. Confocal laser-scanning microscopy revealed colocalization between fluorescent immunomicelles and macrophages in plaques. There was a strong correlation between macrophage content in atherosclerotic plaques and the matched in vivo MRI results as measured by the percent normalized enhancement ratio. Monoclonal antibodies to MSR were able to significantly hinder immunomicelles from providing contrast enhancement of atherosclerotic vessels in vivo . Immunomicelles provided excellent validated in vivo enhancement of atherosclerotic plaques. The enhancement seen is related to the macrophage content of the atherosclerotic vessel areas imaged. Immunomicelles may aid in the detection of high macrophage content associated with plaques vulnerable to rupture.

Integrity signals

Registry

Crossref · 10.1073/pnas.0606281104

Cites

34 of 34 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Inflammation, Atherosclerosis, and Coronary Artery Disease
Hansson, G. K. (2005) · New England Journal of Medicine · doi:10.1056/nejmra043430 · Cited by 8,773
Global mortality, disability, and the contribution of risk factors: Global Burden of Disease Study
Murray, C. J., & Lopez, A. D. (1997) · The Lancet · doi:10.1016/s0140-6736(96)07495-8 · Cited by 4,492
Heart Disease and Stroke Statistics—2006 Update
Writing Group Members, Thom, T., Haase, N., Rosamond, W. D., Howard, V. J., Rumsfeld, J. S., Manolio, T. A., Zheng, Z., Flegal, K. M., O’Donnell, C. J., et al. (2006) · Circulation · doi:10.1161/circulationaha.105.171600 · Cited by 3,453
From Vulnerable Plaque to Vulnerable Patient
Naghavi, M., Libby, P., Falk, E., Casscells, S. W., Litovsky, S. H., Rumberger, J. A., Badimón, J. J., Stefanadis, C., Moreno, P., Pasterkamp, G., et al. (2003) · Circulation · doi:10.1161/01.cir.0000087481.55887.c9 · Cited by 2,679
Self-citation
Binding site on macrophages that mediates uptake and degradation of acetylated low density lipoprotein, producing massive cholesterol deposition
Goldstein, J. L., Ho, Y. K., Basu, S. K., & Brown, M. S. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.1.333 · Cited by 2,447
From Vulnerable Plaque to Vulnerable Patient
Naghavi, M., Libby, P., Falk, E., Casscells, S. W., Litovsky, S. H., Rumberger, J. A., Badimón, J. J., Stefanadis, C., Moreno, P., Pasterkamp, G., et al. (2003) · Circulation · doi:10.1161/01.cir.0000087480.94275.97 · Cited by 2,298
Self-citation
Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells
Plump, A. S., Smith, J. D., Hayek, T., Aalto-Setälä, K., Walsh, A., Verstuyft, J. G., Rubin, E. M., & Breslow, J. L. (1992) · Cell · doi:10.1016/0092-8674(92)90362-g · Cited by 2,263
Sudden Cardiac Death in the United States, 1989 to 1998
Zheng, Z., Croft, J. B., Giles, W. H., & Mensah, G. A. (2001) · Circulation · doi:10.1161/hc4301.098254 · Cited by 1,597
Current Concepts of the Pathogenesis of the Acute Coronary Syndromes
Libby, P. (2001) · Circulation · doi:10.1161/01.cir.104.3.365 · Cited by 1,575
Intraplaque Hemorrhage and Progression of Coronary Atheroma
Kolodgie, F. D., Gold, H. K., BURKE, A. P., Fowler, D. R., Kruth, H. S., Weber, D. K., Farb, A. A., Guerrero, L. J., Hayase, M., Kutys, R., et al. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa035655 · Cited by 1,491

Flagged first, then by citations

Show all 35 references

1 of the 35 references couldn’t be matched to a known paper.

Research works printed but not linked: 1

10.1146/annurev.bi.63.070194.003125 · DOI

Sorted by citations

Items 201–300 of 356

Atherosclerosis and Nanotechnology: Diagnostic and Therapeutic Applications
Kratz, J. D., Chaddha, A., Bhattacharjee, S., & Goonewardena, S. N. (2016) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-016-6649-2 · Cited by 20
Combined non-invasive assessment of endothelial shear stress and molecular imaging of inflammation for the prediction of inflamed plaque in hyperlipidaemic rabbit aortas
Gitsioudis, G., Chatzizisis, Y. S., Wolf, P., Missiou, A., Antoniadis, A. P., Mitsouras, D., Bartling, S. H., Arica, Z., Stuber, M., Rybicki, F. J., et al. (2016) · European Heart Journal - Cardiovascular Imaging · doi:10.1093/ehjci/jew048 · Cited by 19
High resolution magnetic resonance imaging in atherosclerotic mice treated with ezetimibe
Dietrich, T., Hucko, T., Bourayou, R., Jahnke, C., Paetsch, I., Atrott, K., Stawowy, P., Gräfe, M., Klein, C., Schnackenburg, B., et al. (2009) · International journal of cardiac imaging · doi:10.1007/s10554-009-9487-5 · Cited by 19
Combined two‐photon luminescence microscopy and OCT for macrophage detection in the hypercholesterolemic rabbit aorta using plasmonic gold nanorose
Wang, T., Mancuso, J. J., Kazmi, S. M. S., Dwelle, J. C., Sapozhnikova, V. V., Willsey, B., Li, L., Qiu, J., Li, X., Dunn, A. K., et al. (2012) · Lasers in Surgery and Medicine · doi:10.1002/lsm.21153 · Cited by 19
In Vitro Photodynamic Effects of the Inclusion Nanocomplexes of Glucan and Chlorin e6 on Atherogenic Foam Cells
Ahn, J. W., Kim, J. H., & Park, K. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms22010177 · Cited by 18
Recent advances in inhibiting atherosclerosis and restenosis: from pathogenic factors, therapeutic molecules to nano-delivery strategies
Wang, X., Gao, B., & Feng, Y. (2022) · Journal of Materials Chemistry B · doi:10.1039/d2tb00003b · Cited by 20
Characterization and In Vitro and In Vivo Testing of CB2-Receptor- and NGAL-Targeted Paramagnetic Micelles for Molecular MRI of Vulnerable Atherosclerotic Plaque
Boekhorst, B. C. M. T., Bovens, S. M., Rodrigues-Feo, J., Sanders, H. M. H. F., van de Kolk, C. W. A., de Kroon, A. I. P. M., Cramer, M. J., Doevendans, P. A., ten Hove, M., Pasterkamp, G., et al. (2010) · Molecular Imaging and Biology · doi:10.1007/s11307-010-0323-z · Cited by 18
Detection of Macrophages Via Paramagnetic Vesicles Incorporating Oxidatively Tailored Cholesterol Ester: An Approach for Atherosclerosis Imaging
Maiseyeu, A., Mihai, G., Roy, S., Kherada, N. I., Simonetti, O. P., Sen, C. K., Sun, Q., Parthasarathy, S., & Rajagopalan, S. (2010) · Nanomedicine · doi:10.2217/nnm.10.87 · Cited by 18
Advances in molecular imaging of atherosclerosis and myocardial infarction: shedding new light on in vivo cardiovascular biology
Phinikaridou, A., Andía, M. E., Shah, A. M., & Botnar, R. M. (2012) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00583.2012 · Cited by 17
Assessment of Global Cardiac Uptake of Radiolabeled Iron Oxide Nanoparticles in Apolipoprotein-E-Deficient Mice: Implications for Imaging Cardiovascular Inflammation
de Barros, A. L. B., Chacko, A., Mikitsh, J. L., Zaki, A. A., Salavati, A., Saboury, B., Tsourkas, A., & Alavi, A. A. (2013) · Molecular Imaging and Biology · doi:10.1007/s11307-013-0709-9 · Cited by 17
Monitoring Vascular Permeability and Remodeling After Endothelial Injury in a Murine Model Using a Magnetic Resonance Albumin-Binding Contrast Agent
Lavín, B., Phinikaridou, A., Lorrio, S., Zaragoza, C., & Botnar, R. M. (2015) · Circulation Cardiovascular Imaging · doi:10.1161/circimaging.114.002417 · Cited by 17
In vivo MRI detection of atherosclerosis in ApoE-deficient mice by using tenascin-C-targeted USPIO
Li, Y., Liu, J., Huang, J., Song, J., Ma, Z., & Shi, H. (2018) · Acta Radiologica · doi:10.1177/0284185118762613 · Cited by 17
An innovative flow cytometry method to screen human scFv-phages selected by in vivo phage-display in an animal model of atherosclerosis
Hémadou, A., Laroche‐Traineau, J., Antoine, S., Mondon, P., Fontayne, A., Priol, Y. L., Claverol, S., Sanchez, S., Cérutti, M., Ottonès, F., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-33382-2 · Cited by 19
Advanced targeted nanomedicines for vulnerable atherosclerosis plaque imaging and their potential clinical implications
Li, X., Wu, M., Li, J., Guo, Q., Zhao, Y., & Zhang, X. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.906512 · Cited by 16
Molecular magnetic resonance imaging of atherosclerotic vessel wall disease
Nörenberg, D., Ebersberger, H. U., Diederichs, G., Hamm, B., Botnar, R. M., & Makowski, M. R. (2015) · European Radiology · doi:10.1007/s00330-015-3881-2 · Cited by 16
Molecular and Nonmolecular Magnetic Resonance Coronary and Carotid Imaging
Hajhosseiny, R., Bahaei, T. S., Prieto, C., & Botnar, R. M. (2019) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.118.311754 · Cited by 16
Molecular imaging of innate immunity and immunotherapy
Xia, W., Singh, N., Goel, S., & Shi, S. (2023) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2023.114865 · Cited by 15
Effect of Ligand Structure on MnO Nanoparticles for Enhanced T1 Magnetic Resonance Imaging of Inflammatory Macrophages
Park, J., Bang, D., Kim, E., Yang, J., Lim, E., Choi, J., Kang, B., Suh, J., Park, H. S., Huh, Y., et al. (2012) · European Journal of Inorganic Chemistry · doi:10.1002/ejic.201201026 · Cited by 15
Visualizing the atherosclerotic plaque: a chemical perspective
Albelda, M. T., García‐España, E., & Frias, J. C. (2014) · Chemical Society Reviews · doi:10.1039/c3cs60410a · Cited by 15
Self-citation
Imaging of hypoxia in mouse atherosclerotic plaques with 64Cu-ATSM
Nie, X., Randolph, G. J., Elvington, A., Bandara, N., Zheleznyak, A., Gropler, R. J., Woodard, P. K., & Lapi, S. E. (2016) · Nuclear Medicine and Biology · doi:10.1016/j.nucmedbio.2016.05.011 · Cited by 15
Nanomedicine for the molecular diagnosis of cardiovascular pathologies
Juenet, M., Varna, M., Aid, R., Chauvierre, C., & Letourneur, D. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.06.138 · Cited by 18
Cardiovascular Magnetic Resonance Imaging in Small Animals
Botnar, R. M., & Makowski, M. R. (2011) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-394596-9.00008-1 · Cited by 15
A design strategy for small molecule-based targeted MRI contrast agents: their application for detection of atherosclerotic plaques
Iwaki, S., Hokamura, K., Ogawa, M., Takehara, Y., Muramatsu, Y., Yamane, T., Hirabayashi, K., Morimoto, Y., Hagisawa, K., Nakahara, K., et al. (2014) · Organic & Biomolecular Chemistry · doi:10.1039/c4ob01270d · Cited by 16
Molecular Magnetic Resonance Imaging with Contrast Agents for Assessment of Inflammatory Bowel Disease: A Systematic Review
Luo, Y., Gao, C., Chen, W., Zhou, K., & Xu, M. (2020) · Contrast Media & Molecular Imaging · doi:10.1155/2020/4764985 · Cited by 14
Macrophage-Targeted Nanoparticle Delivery Systems
Jain, S., & Amiji, M. M. (2012) · Nanostructure science and technology · doi:10.1007/978-1-4614-2305-8_4 · Cited by 14
MRI-based assessment of endothelial function in mice in vivo
Bar, A., Skórka, T., Jasiński, K., & Chłopicki, S. (2015) · Pharmacological Reports · doi:10.1016/j.pharep.2015.05.007 · Cited by 14
Molecular Imaging With Targeted Contrast Agents
Makowski, M. R., Wiethoff, A. J., Jansen, C. H. P., & Botnar, R. M. (2009) · Topics in Magnetic Resonance Imaging · doi:10.1097/rmr.0b013e3181ea28b1 · Cited by 13
Principles and basic concepts of molecular imaging
Grenier, N., & Brader, P. (2010) · Pediatric Radiology · doi:10.1007/s00247-010-1835-z · Cited by 13
Molecular Imaging of Acute Cardiac Transplant Rejection
Chen, Y., Zhang, L., Liu, J., Zhang, P., Chen, X. S., & Xie, M. (2017) · Transplantation · doi:10.1097/tp.0000000000001780 · Cited by 13
Molecular Imaging in Cardiovascular Diseases
Botnar, R. M., Ebersberger, H. U., Noerenberg, D., Jansen, C. H. P., Wiethoff, A. J., Schuster, A., Kasner, M., Walter, T., Knobloch, G., Höppe, P., et al. (2015) · RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren · doi:10.1055/s-0034-1385451 · Cited by 13
The Year in Atherothrombosis
Sanz, J., Moreno, P., & Fuster, V. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.12.018 · Cited by 13
The Complex Fate in Plasma of Gadolinium Incorporated into High-Density Lipoproteins Used for Magnetic Imaging of Atherosclerotic Plaques
Barazza, A., Blachford, C., Even‐Or, O., Joaquin, V. A., Briley-Saebo, K. C., Chen, W., Jiang, X., Mulder, W. J. M., Cormode, D. P., Fayad, Z. A., et al. (2013) · Bioconjugate Chemistry · doi:10.1021/bc400105j · Cited by 12
Self-citation
Anti-angiogenic drug loaded liposomes: Nanotherapy for early atherosclerotic lesions in mice
Pont, I., Calatayud-Pascual, M. A., López‐Castellano, A., Albelda, E. P., García‐España, E., Martí‐Bonmatí, L., Frias, J. C., & Albelda, M. T. (2018) · PLoS ONE · doi:10.1371/journal.pone.0190540 · Cited by 12
Self-citation
Naposomes: a New Class of peptide-derivatized, target-selective Multimodal Nanoparticles for Imaging and Therapeutic Applications
Accardo, A., Morisco, A., Tesauro, D., Pedone, C., & Morelli, G. (2011) · Therapeutic Delivery · doi:10.4155/tde.10.86 · Cited by 12
Hipertensión pulmonar: nuevos conocimientos a través de tecnología de imagen
Fuster, V., & Sanz, J. (2007) · Revista Española de Cardiología · Cited by 12
Imaging the Cellular Biology of the Carotid Plaque
U‐King‐Im, J. M., Tang, T. Y., Moustafa, R. R., Baron, J., Warburton, E. A., & Gillard, J. H. (2007) · International Journal of Stroke · doi:10.1111/j.1747-4949.2007.00123.x · Cited by 12
M1-Activated Macrophages Migration, A Marker of Aortic Atheroma Progression
Bessaad, A., Sigovan, M., Alsaid, H., Souza, G. D., Provost, N., Majd, Z., Ménager, C., Honnorat, J., Lagarde, F., Nighoghossian, N., et al. (2010) · Investigative Radiology · doi:10.1097/rli.0b013e3181d78030 · Cited by 11
Diabetes and Cardiovascular Disease
Johnstone, M. T., & Veves, A. (2023) · Contemporary cardiology · doi:10.1007/978-3-031-13177-6 · Cited by 12
Imaging of Atherosclerosis
Wick, M. C., Chemelli-Steingruber, I. E., & Kremser, C. (2011) · Springer eBooks · doi:10.1007/978-3-7091-0338-8_29 · Cited by 12
Nanoparticles in medical imaging
Kalra, J., Krishna, V., Reddy, B. S. V., Dhar, A., Venuganti, V. V. K., & Bhat, A. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-821163-2.00010-8 · Cited by 10
Nanostructures based on monoolein or diolein and amphiphilic gadolinium complexes as MRI contrast agents
Accardo, A., Gianolio, E., Arena, F., Barnert, S., Schubert, R., Tesauro, D., & Morelli, G. (2012) · Journal of Materials Chemistry B · doi:10.1039/c2tb00329e · Cited by 10
Nanomaterial-Mediated Theranostics for Vascular Diseases
Agrawal, S., Nooti, S. K., Singh, H., & Rai, V. (2020) · Journal of Nanotheranostics · doi:10.3390/jnt2010001 · Cited by 9
In vivo molecular imaging of vascular stress
Wick, M. C., Kremser, C., Frischauf, S., & Wick, G. (2008) · Cell Stress and Chaperones · doi:10.1007/s12192-008-0043-3 · Cited by 9
Molecular Imaging in Ischemic Heart Disease
Lavín, B., Theodoulou, I., Rashid, I., Hajhosseiny, R., Phinikaridou, A., & Botnar, R. M. (2019) · Current Cardiovascular Imaging Reports · doi:10.1007/s12410-019-9500-x · Cited by 9
Imaging outcomes in cardiovascular clinical trials
Razzouk, L., & Farkouh, M. E. (2009) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2009.104 · Cited by 9
Liposomal Contrast Agents in Brain Tumor Imaging
Ghaghada, K. B., Colen, R. R., Hawley, C. R., Patel, N., & Mukundan, S. (2010) · Neuroimaging Clinics of North America · doi:10.1016/j.nic.2010.05.001 · Cited by 7
Accelerating three‐dimensional molecular cardiovascular MR imaging using compressed sensing
Prieto, C., Andía, M. E., von Bary, C., Onthank, D. C., Schaeffter, T., & Botnar, R. M. (2012) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.23763 · Cited by 8
Bimodal Fluorescence and Magnetic Resonance Imaging Using Water-Soluble Hexagonal NaYF4:Ce,Tb,Gd Nanocrystals
Ren, W. T., Liang, L. B., Qi, F., Sun, Z. B., Yang, Z. Y., Huang, X. Q., Wu, Q. Z., Zhu, H. Y., Yu, X., Quan, H., et al. (2011) · Journal of Nanomaterials · doi:10.1155/2011/531217 · Cited by 8
Molecular MRI of atherosclerotic plaque with targeted contrast agents
Sosnovik, D. E., & Caravan, P. D. (2009) · Current Cardiovascular Imaging Reports · doi:10.1007/s12410-009-0012-y · Cited by 8
In vivo MRI detection of intraplaque macrophages with biocompatible silica-coated iron oxide nanoparticles in murine atherosclerosis
Kim, C. W., Hwang, B., Moon, H., Kang, J., Park, E.-H., Ihm, S., Chang, K., & Hong, K. S. (2021) · Journal of Applied Biomaterials & Functional Materials · doi:10.1177/22808000211014751 · Cited by 7
Nanoparticles as Contrast Agents for MRI of Atherosclerotic Lesions
Frias, J. C., Lipinski, M. J., Albelda, M. T., Ibáñez, B., Soriano, C., García‐España, E., Jiménez‐Borreguero, L. J., & Badimón, J. J. (2008) · Clinical medicine Cardiology · doi:10.4137/cmc.s642 · Cited by 7
Self-citation
Recent developments and new perspectives on imaging of atherosclerotic plaque: role of anatomical, cellular and molecular MRI part III
Boekhorst, B. C. M. T., Cramer, M. J., Pasterkamp, G., van Echteld, C. J. A., & Doevendans, P. A. (2010) · International journal of cardiac imaging · doi:10.1007/s10554-009-9566-7 · Cited by 7
Atherosclerosis and Thrombosis
Choudhury, R. P. (2007) · Topics in Magnetic Resonance Imaging · doi:10.1097/rmr.0b013e3181598dd8 · Cited by 7
Molecular Imaging of Brain Tumors Using Liposomal Contrast Agents and Nanoparticles
Mehta, A., Ghaghada, K. B., & Mukundan, S. (2016) · Magnetic Resonance Imaging Clinics of North America · doi:10.1016/j.mric.2016.06.004 · Cited by 7
Structural insights on nanoparticles containing gadolinium complexes as potential theranostic
Accardo, A., Ringhieri, P., Szekely, N. K., Pipich, V., Luchini, A., Paduano, L., & Tesauro, D. (2014) · Colloid & Polymer Science · doi:10.1007/s00396-013-3159-7 · Cited by 6
Emerging Nuclear Medicine Imaging of Atherosclerotic Plaque Formation
Kondakov, A. K., Berdalin, A. B., Beregov, M. M., & Lelyuk, V. G. (2022) · Journal of Imaging · doi:10.3390/jimaging8100261 · Cited by 6
Cardiovascular Nanomedicine: Challenges and Opportunities
Godin, B., Hu, Y., Francesca, S. L., & Mauro Ferrari, B. (2012) · Humana Press eBooks · doi:10.1007/978-1-61779-906-8_9 · Cited by 6
The time window of MRI of murine atherosclerotic plaques after administration of CB2 receptor targeted micelles: inter‐scan variability and relation between plaque signal intensity increase and gadolinium content of inversion recovery prepared versus non‐prepared fast spin echo
Boekhorst, B. C. M. T., Bovens, S. M., van de Kolk, C. W. A., Cramer, M. J., Doevendans, P. A., ten Hove, M., van der Weerd, L., Poelmann, R. E., Strijkers, G. J., Pasterkamp, G., et al. (2010) · NMR in Biomedicine · doi:10.1002/nbm.1514 · Cited by 6
Inductive heating kills cells that contribute to plaque: a proof-of-concept
Gaitas, A., & Kim, G. (2015) · PeerJ · doi:10.7717/peerj.929 · Cited by 6
Recent Advances in Visualizing Vulnerable Plaque: Focus on Noninvasive Molecular Imaging
Bala, G., & Cosyns, B. (2014) · Current Cardiology Reports · doi:10.1007/s11886-014-0520-5 · Cited by 6
Cardiovascular MRI in small animals
Makowski, M. R., Wiethoff, A. J., Jansen, C. H. P., & Botnar, R. M. (2009) · Expert Review of Cardiovascular Therapy · doi:10.1586/erc.09.126 · Cited by 6
Recent Advances in the Molecular Imaging of Atherosclerosis
Larivière, M., Bonnet, S., Lorenzato, C., Laroche‐Traineau, J., Ottonès, F., Jacobin‐Valat, M., & Clofent‐Sanchez, G. (2020) · Seminars in Thrombosis and Hemostasis · doi:10.1055/s-0039-1701019 · Cited by 7
Imaging Biomarkers of Atherosclerosis
Noble, S., Heinonen, T. M., & Tardif, J. (2008) · Biomarkers in Medicine · doi:10.2217/17520363.2.6.555 · Cited by 5
Approaching the Asymptote: Obstacles and Opportunities for Nanomedicine in Cardiovascular Disease
Goonewardena, S. N. (2012) · Current Atherosclerosis Reports · doi:10.1007/s11883-012-0249-9 · Cited by 6
New insights to atherosclerosis management: Role of nanomaterials
Li, Z., Jiang, C. S., Chai, L., Fan, T., Li, C., Chen, Z., Huang, W., Zhang, B., Al‐Hartomy, O. A., Al‐Ghamdi, A. A., et al. (2022) · Applied Materials Today · doi:10.1016/j.apmt.2022.101466 · Cited by 5
Advances in contrast media for vascular imaging of atherosclerosis
Young, V. E. L., Degnan, A. J., & Gillard, J. H. (2011) · Imaging in Medicine · doi:10.2217/iim.11.23 · Cited by 5
Nanomedicine: Tiny Particles and Machines, from Diagnosis to Treatment of Cardiovascular Disease, Provides Huge Achievements
Ismail, M. Y., Hossain, M. F., Karim, M. F., & Shekhar, H. U. (2015) · Advances in Bioscience and Biotechnology · doi:10.4236/abb.2015.69064 · Cited by 5
Molecular Cardiovascular Magnetic Resonance: Current Status and Future Prospects
Bender, Y. Y., Pfeifer, A., Ebersberger, H. U., Diederichs, G., Höppe, P., Hamm, B., Botnar, R. M., & Makowski, M. R. (2016) · Current Cardiology Reports · doi:10.1007/s11886-016-0719-8 · Cited by 5
Noninvasive Molecular Imaging of Mouse Atherosclerosis
McAteer, M. A., & Choudhury, R. P. (2015) · Methods in molecular biology · doi:10.1007/978-1-4939-2929-0_4 · Cited by 5
The Year in Molecular Imaging
Osborn, E. A., & Jaffer, F. A. (2009) · JACC. Cardiovascular imaging · doi:10.1016/j.jcmg.2008.11.001 · Cited by 5
Scavenger Receptors
Gordon, S., & Neyen, C. D. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-394447-4.30110-9 · Cited by 5
Novel cutting edge nano‐strategies to address old long‐standing complications in cardiovascular diseases. A comprehensive review
Tesoro, L., Hernández, I., Saura, M., Badimón, L., & Zaragoza, C. (2024) · European Journal of Clinical Investigation · doi:10.1111/eci.14208 · Cited by 4
Targeted Nanoparticles for Cardiovascular Molecular Imaging
Strijkers, G. J. (2013) · Current Radiology Reports · doi:10.1007/s40134-013-0017-9 · Cited by 4
Self-Gated CINE MRI for Combined Contrast-Enhanced Imaging and Wall-Stiffness Measurements of Murine Aortic Atherosclerotic Lesions
den Adel, B., van der Graaf, L. M., Strijkers, G. J., Lamb, H. J., Poelmann, R. E., & van der Weerd, L. (2013) · PLoS ONE · doi:10.1371/journal.pone.0057299 · Cited by 4
Cardiomyocyte Death: Insights from Molecular and Microstructural Magnetic Resonance Imaging
Berry, N. C., & Sosnovik, D. E. (2011) · Pediatric Cardiology · doi:10.1007/s00246-011-9894-y · Cited by 4
Modified Lipoproteins As Contrast Agents For Molecular Imaging
Cormode, D. P., Mulder, W. J. M., Fisher, E. A. A., & Fayad, Z. A. (2007) · Future Lipidology · doi:10.2217/17460875.2.6.587 · Cited by 4
Self-citation
Coronary MR Imaging: Lumen and Wall
Kelle, S., Weiss, R. G., & Stuber, M. (2009) · Magnetic Resonance Imaging Clinics of North America · doi:10.1016/j.mric.2008.12.003 · Cited by 4
Cardiovascular Magnetic Resonance Contrast Agents
Caravan, P. D. (2010) · Elsevier eBooks · doi:10.1016/b978-0-443-06686-3.00006-0 · Cited by 4
Atherosclerotic Plaque Imaging
Lavín, B., Gebhardt, P., Phinikaridou, A., & Botnar, R. M. (2017) · Springer eBooks · doi:10.1007/978-3-319-53001-7_8 · Cited by 3
Non-invasive Assessment of Coronary Artery Disease: The Role of AI in the Current Status and Future Directions
Ezekwueme, F., Tolu-Akinnawo, O. Z., Smith, Z., & Ogunniyi, K. E. (2025) · Cureus · doi:10.7759/cureus.78994 · Cited by 4
Acoustic Radiation Force Optical Coherence Elastography
Qu, Y., He, Y., Ma, T., Zhou, Q., & Chen, Z. (2019) · Springer eBooks · doi:10.1007/978-981-10-6307-7_9 · Cited by 3
Molecular MR Imaging of Atherosclerosis
Moonen, R. P. M., Strijkers, G. J., Fayad, Z. A., Daemen, M. J. A. P., & Nicolay, K. (2014) · Springer eBooks · doi:10.1007/978-3-319-09268-3_13 · Cited by 3
Self-citation
Current Development of Molecular Coronary Plaque Imaging using Magnetic Resonance Imaging towards Clinical Application
Lavín, B., Phinikaridou, A., Henningsson, M., & Botnar, R. M. (2014) · Current Cardiovascular Imaging Reports · doi:10.1007/s12410-014-9309-6 · Cited by 3
Nanomedicine in Cardiovascular Diseases: Emerging Diagnostic and Therapeutic Potential
Sureddi, R. K., & Mehta, J. L. (2011) · Journal of Nanotechnology in Engineering and Medicine · doi:10.1115/1.4005490 · Cited by 3
Metals in Medicine: Imaging Agents
Caravan, P. D. (2008) · Wiley Encyclopedia of Chemical Biology · doi:10.1002/9780470048672.wecb332 · Cited by 3
Atherosclerosis Monitoring in the Elderly Using Magnetic Resonance Imaging: Is the Extra Step Needed?
Gottlieb, I., Xavier, S. S., & Lima, J. A. C. (2007) · The American Journal of Geriatric Cardiology · doi:10.1111/j.1076-7460.2007.07638.x · Cited by 3
Acoustic Radiation Force Optical Coherence Elastography
Chen, Z. (2014) · Asia Communications and Photonics Conference · doi:10.1364/acpc.2014.ath4h.2 · Cited by 2
Chemistry of Molecular Imaging: An Overview
Aime, S., Travagin, F., Terreno, E., & Giovenzana, G. B. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-816386-3.00029-6 · Cited by 2
Fullerenes and Their Potential in Nanomedicine
Kelkar, A. D., Herr, D. J. C., & Ryan, J. G. (2014) · CRC Press eBooks · doi:10.1201/b16957-13 · Cited by 2
Visualización de la guerra macrofágica arterial con resonancia magnética nuclear, tomografía de emisión de positrones y tomografía computarizada
Fuster, V., & Sanz, J. (2009) · Revista Española de Cardiología · doi:10.1016/s0300-8932(09)72116-5 · Cited by 2
Macrophage Heterogeneity
Gordon, S. (2012) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.111.238139 · Cited by 2
Imaging of vascular biology in the heart
Tavakoli, S., & Sadeghi, M. M. (2009) · Current Cardiovascular Imaging Reports · doi:10.1007/s12410-009-0006-9 · Cited by 2
MRI, the technology for imaging of thrombi and inflammation
Bode, C., & Mühlen, C. V. Z. (2015) · Hämostaseologie · doi:10.5482/hamo-14-11-0061 · Cited by 2
Synthesis of Dihexyldithiophosphate Ligand and a Preliminary Study on Its Use for the Extraction of Gadolinium from Rare Earth Elements Mixture
Wyantuti, S., Pratomo, U., Aprilani, M., Anggraeni, A., & Bahti, H. H. (2019) · Key engineering materials · doi:10.4028/www.scientific.net/kem.829.270 · Cited by 2
Cardiovascular System
Raftis, J. B., Mills, N. L., & Duffin, R. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-386940-1.00008-8 · Cited by 2
Atherosclerosis
Owens, C. D., & Conte, M. S. (2010) · Elsevier eBooks · doi:10.1016/b978-1-4160-5223-4.00004-4 · Cited by 2
Cardiovascular Molecular Imaging
Morrison, A., Wu, J. C., & Sadeghi, M. M. (2015) · Oxford University Press eBooks · doi:10.1093/med/9780199392094.003.0029 · Cited by 2
Microparticle-Based Molecular MRI of Atherosclerosis, Thrombosis, and Tissue Ischemia
Mankia, K. S., McAteer, M. A., & Choudhury, R. P. (2010) · Current Cardiovascular Imaging Reports · doi:10.1007/s12410-010-9059-z · Cited by 2
Glycosaminoglycans as Novel Targets for in vivo Contrast-Enhanced Magnetic Resonance Imaging of Atherosclerosis
Uca, Y. O., & Taupitz, M. (2020) · Journal of Cardiology and Cardiovascular Medicine · doi:10.29328/journal.jccm.1001091 · Cited by 2
Magnetic Resonance Imaging Contrast Agents
Bonnet, C. S., & Tóth, É. (2012) · Supramolecular chemistry · doi:10.1002/9780470661345.smc104 · Cited by 2

Authors: Amirbekian, V., Lipinski, M. J., Briley-Saebo, K. C., Amirbekian, S., Aguinaldo, J. G. S., Weinreb, D. B., Vucic, E., Frias, J. C., Hyafil, F., Mani, V., Fisher, E. A., & Fayad, Z. A.
Affiliations: Johns Hopkins University (US)
Sarnoff Cardiovascular Research Foundation (US)
Icahn School of Medicine at Mount Sinai (US)
Emory University (US)
New York University (US)
ORCID: Briley-Saebo, Karen C.
Vucic, Esad
Frias, Juan C.
Hyafil, Fabien
Mani, Venkatesh
Fisher, Edward A.
Fayad, Zahi A.
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2007-01-16
Volume: 104
Issue: 3
Pages: 961-966
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.0606281104
PMC: PMC1766334
OpenAlex: W1986805734
Cited by: 356
References: 35
Citations by year: 2026: 1 · 2025: 1 · 2024: 3 · 2023: 4 · 2022: 9 · 2021: 4 · 2020: 12 · 2019: 14 · 2018: 7 · 2017: 13 · 2016: 14 · 2015: 23 · 2014: 26 · 2013: 19 · 2012: 38
FWCI: 17.16
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Science Foundation (9724504, 1 S10 RR0 9145-01)
Sarnoff Cardiovascular Research Foundation
National Institutes of Health (1s10rr009145-01, 1S10 RR0 9145-01)
National Heart, Lung, and Blood Institute (R01HL078667, U01 HL 71021, R01HL071021, U01HL070524)
National Cancer Institute (R24CA095823)
National Center for Research Resources (1 S10RR0 9145-01)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Keywords: atherosclerosis, macrophages, molecular MRI, macrophage scavenger receptor, targeted contrast agents, non-invasive imaging, atherosclerotic plaque, plaque vulnerability, ApoE-deficient mice, Gd-DTPA, monoclonal antibodies, macrophage content
MeSH terms: Animals, Apolipoproteins E, Macrophages, Magnetic Resonance Imaging, Micelles, Microscopy, Confocal, Atherosclerosis, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Detecting and assessing macrophages in vivo to evaluate atherosclerosis noninvasively using molecular MRI

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks