Maternal serotonin is crucial for murine embryonic development
Open accessAbstract
The early appearance of serotonin and its receptors during prenatal development, together with the many effects serotonin exerts during CNS morphogenesis, strongly suggest that serotonin influences the development and maturation of the mammalian brain before it becomes a neuromodulator/neurotransmitter. Sites of early serotonin biosynthesis, however, have not been detected in mouse embryos or extraembryonic structures, suggesting that the main source of serotonin could be of maternal origin. This hypothesis was tested by using knockout mice lacking the tph1 gene, which is responsible for the synthesis of peripheral serotonin. Genetic crosses were performed to compare the phenotype of pups born from homozygous and heterozygous mothers. Observations provide the first clear evidence that ( i ) maternal serotonin is involved in the control of morphogenesis during developmental stages that precede the appearance of serotonergic neurons and ( ii ) serotonin is critical for normal murine development. Most strikingly, the phenotype of tph1 −/− embryos depends more on the maternal genotype than on that of the concepti. Consideration of the maternal genotype may thus help to clarify the influence of other genes in complex diseases, such as mental illness.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Gut microbiota manufactures neuroactive chemicals and influences levels of circulating 5-HT and serotonin, thereby altering fetal neuronal cell synaptogenesis and neuronal morphogenesis.
“Furthermore, gut microbiota manufactures neuroactive chemicals and influences levels of circulating 5-hydroxytryptamine (5-HT) and serotonin, thereby altering fetal neuronal cell synaptogenesis [89] and neuronal morphogenesis [90], respectively.”
From Gut microbiota changes in children with autism spectrum disorder: a systematic review (2020) · cites this paper as [90]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
The citation lists haven’t been fetched yet
References 36 · Cited by 381
Research works printed but not linked: 1
- [10]Lauder JM, Zimmermann EF. J Craniofac Genet Dev Biol. 1988;8:265–276. [[PubMed](https://pubmed.ncbi.nlm.nih.gov/3209688/)] [[Google Scholar](https://scholar.google.com/scholar_lookup?journal=J%20Craniofac%20Genet%20Dev%20Biol&author=JM%20Lauder&author=EF%20Zimmermann&volume=8&publication_year=1988&pages=265-276&pmid=3209688&)]
- Authors
- Côté, F., Fligny, C., Bayard, E., Launay, J.-M., Gershon, M. D., Mallet, J., & Vodjdani, G.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Hôpital Lariboisière (FR)
- Columbia University (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2007-01-02
- Volume
- 104
- Issue
- 1
- Pages
- 329-334
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC1713169
- OpenAlex
- W2098331502
- Cited by
- 381
- References
- 36
- Citations by year
- 2026: 13 · 2025: 9 · 2024: 16 · 2023: 16 · 2022: 19 · 2021: 23 · 2020: 28 · 2019: 18 · 2018: 31 · 2017: 11 · 2016: 14 · 2015: 20 · 2014: 20 · 2013: 23 · 2012: 21
- FWCI
- 5.74
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- embryonic development, serotonin synthesis, maternal genotype, serotonergic neurons, extraembryonic tissues, mouse embryo, psychiatric genetics
- MeSH terms
- Animals, Genotype, Mice, Inbred C57BL, Phenotype, Phenylketonurias, RNA, Messenger, Serotonin, Tryptophan Hydroxylase, Signal Transduction, Embryonic Development, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
