The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
TGFβ promotes conversion of CD16 + peripheral blood NK cells into CD16 − NK cells with similarities to decidual NK cells
Open accessAbstract
During pregnancy the uterine decidua is populated by large numbers of natural killer (NK) cells with a phenotype CD56 superbright CD16 − CD9 + KIR + distinct from both subsets of peripheral blood NK cells. Culture of highly purified CD16 + CD9 − peripheral blood NK cells in medium containing TGFβ1 resulted in a transition to CD16 − CD9 + NK cells resembling decidual NK cells. Decidual stromal cells, when isolated and cultured in vitro , were found to produce TGFβ1. Incubation of peripheral blood NK cells with conditioned medium from decidual stromal cells mirrored the effects of TGFβ1. Similar changes may occur upon NK cell entry into the decidua or other tissues expressing substantial TGFβ. In addition, Lin − CD34 + CD45 + hematopoietic stem/progenitor cells could be isolated from decidual tissue. These progenitors also produced NK cells when cultured in conditioned medium from decidual stromal cells supplemented with IL-15 and stem cell factor.
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Citations
Cites
Tetraspanin functions and associated microdomains
Hemler, M. E. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1736 · Cited by 1,355
Natural killer cells and pregnancy
Moffett-King, A. (2002) · Nature Reviews Immunology · doi:10.1038/nri886 · Cited by 1,235
Cited by
Fetomaternal immune cross-talk and its consequences for maternal and offspring's health
Arck, P. C., & Hecher, K. (2013) · Nature Medicine · doi:10.1038/nm.3160 · Cited by 600
Organ-specific features of natural killer cells
Shi, F.-D., Ljunggren, H.-G., La Cava, A., & Van Kaer, L. (2011) · Nature Reviews Immunology · doi:10.1038/nri3065 · Cited by 414
Uterine NK cells and macrophages in pregnancy
Faas, M. M., & de Vos, P. (2017) · Placenta · doi:10.1016/j.placenta.2017.03.001 · Cited by 312
Trained Memory of Human Uterine NK Cells Enhances Their Function in Subsequent Pregnancies
Gamliel, M., Goldman-Wohl, D., Isaacson, B., Gur, C., Stein, N., Yamin, R., Berger, M., Grunewald, M., Keshet, E., Rais, Y., et al. (2018) · Immunity · doi:10.1016/j.immuni.2018.03.030 · Cited by 312
The role of decidual immune cells on human pregnancy
Liu, S., Diao, L., Huang, C., Li, Y., Zeng, Y., & Kwak-Kim, J. Y. H. (2017) · Journal of Reproductive Immunology · doi:10.1016/j.jri.2017.10.045 · Cited by 308
Metadata
- Authors
- Keskin, D. B., Allan, D. S. J., Rybalov, B., Andzelm, M. M., Stern, J. N. H., Kopcow, H. D., Koopman, L. A., & Strominger, J. L.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2007-02-27
- Volume
- 104
- Issue
- 9
- Pages
- 3378-3383
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2093227175
- Cited by
- 370
- References
- 2
- FWCI
- 5.70
- Type
- journal article
- Language
- en
- Open access
- green
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- The paper
- Keskin, D. B., Allan, D. S. J., Rybalov, B., Andzelm, M. M., Stern, J. N. H., Kopcow, H. D., Koopman, L. A., & Strominger, J. L. (2007). TGFβ promotes conversion of CD16 + peripheral blood NK cells into CD16 − NK cells with similarities to decidual NK cells. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0611098104
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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