The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
HIV controllers exhibit potent CD8 T cell capacity to suppress HIV infection ex vivo and peculiar cytotoxic T lymphocyte activation phenotype
Open accessAbstract
Some rare HIV-1-infected individuals, referred to as HIV controllers (HIC), have persistently undetectable plasma viral load in the absence of therapy. This control of HIV-1 replication has been associated with a strong, multifunctional specific CD8 + T cell response. However, no direct link between this immune response and the control of viremia has so far been provided. We investigated parameters of specific CD8 + T cell response and in vitro susceptibility to HIV-1 infection in 11 HIC. We found high frequencies of HIV-specific CD8 + T cells. Interestingly, these cells expressed the activation marker HLA-DR but not CD38. This unique phenotype differentiates HIV-specific CD8 + T cells from HIC and noncontroller subjects and likely reflects a high potential to expand upon exposure to antigen and a capacity to exert effector functions. Accordingly, although CD4 + T cells from HIC were fully susceptible to HIV-1 superinfection, their CD8 + T cells effectively suppressed HIV-1 infection. Remarkably, this potent anti-HIV activity was observed without prior stimulation of CD8 + T cells. This activity was not mediated by secreted inhibitory factors but was due to the elimination of infected CD4 + T cells and was observed only with autologous CD4 + T cells, indicating an HLA-restricted cytotoxic mechanism. This constitutive antiviral capacity of CD8 + T cells could account for the control of viral replication in HIC.
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CD8+ T cell efficacy in vaccination and disease
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CD8+ T cells in HIV control, cure and prevention
Collins, D. R., Gaiha, G. D., & Walker, B. D. (2020) · Nature Reviews Immunology · doi:10.1038/s41577-020-0274-9 · Cited by 303
Development and use of SIV-based Integrase defective lentiviral vector for immunization
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Metadata
- Authors
- Sáez-Cirión, A., Lacabaratz, C., Lambotte, O., Versmisse, P., Urrutia, A., Boufassa, F., Barré-Sinoussi, F., Delfraissy, J.-F., Sinet, M., Pancino, G., & Venet, A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2007-04-17
- Volume
- 104
- Issue
- 16
- Pages
- 6776-6781
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2079280846
- Cited by
- 616
- References
- 36
- FWCI
- 12.68
- Type
- journal article
- Language
- en
- Open access
- green
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- Sáez-Cirión, A., Lacabaratz, C., Lambotte, O., Versmisse, P., Urrutia, A., Boufassa, F., Barré-Sinoussi, F., Delfraissy, J.-F., Sinet, M., Pancino, G., & Venet, A. (2007). HIV controllers exhibit potent CD8 T cell capacity to suppress HIV infection ex vivo and peculiar cytotoxic T lymphocyte activation phenotype. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0611244104
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