The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Identification of a human CD8 + regulatory T cell subset that mediates suppression through the chemokine CC chemokine ligand 4
Open accessAbstract
Regulatory T cells (Treg) comprise multiple subsets and are important in controlling immunity and inflammation. However, the induction and mode of action of the various distinct Treg subsets remain ill defined, particularly in humans. Here, we describe a human CD8 + lymphocyte activation gene-3 (LAG-3) + CD25 + FoxP3 + Treg subset, which suppresses T cells partly through the secretion of CC chemokine ligand 4 (CCL4), which can inhibit T cell activation by interfering with T cell receptor signaling. CD8 + Tregs are expanded by antigen in in vivo -primed donors, and can be detected in pathogen-infected human tissue. This CD8 + LAG-3 + CD25 + FoxP3 + CCL4 + Treg subset thus may play a role in immunoregulation in humans, including infectious diseases.
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Citations
Cites
Sakaguchi, S. (2005) · Nature Immunology · doi:10.1038/ni1178 · Cited by 2,669
Cited by
Molecular and cellular insights into T cell exhaustion
Wherry, E. J., & Kurachi, M. (2015) · Nature Reviews Immunology · doi:10.1038/nri3862 · Cited by 4,652
Wherry, E. J. (2011) · Nature Immunology · doi:10.1038/ni.2035 · Cited by 4,062
Camisaschi, C., Casati, C., Rini, F., Perego, M., De Filippo, A., Triebel, F., Parmiani, G., Belli, F., Rivoltini, L., & Castelli, C. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903879 · Cited by 350
Metadata
- Authors
- Joosten, S. A., van Meijgaarden, K. E., Savage, N. D. L., de Boer, T., Triebel, F., van der Wal, A., de Heer, E., Klein, M. R., Geluk, A., & Ottenhoff, T. H. M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2007-05-08
- Volume
- 104
- Issue
- 19
- Pages
- 8029-8034
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2123518168
- Cited by
- 185
- References
- 1
- FWCI
- 7.13
- Type
- journal article
- Language
- en
- Open access
- green
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- Joosten, S. A., van Meijgaarden, K. E., Savage, N. D. L., de Boer, T., Triebel, F., van der Wal, A., de Heer, E., Klein, M. R., Geluk, A., & Ottenhoff, T. H. M. (2007). Identification of a human CD8 + regulatory T cell subset that mediates suppression through the chemokine CC chemokine ligand 4. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0702257104
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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