The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Prandiology of Drosophila and the CAFE assay
Open accessAbstract
Studies of feeding behavior in genetically tractable invertebrate model systems have been limited by the lack of proper methodology. We introduce the Capillary Feeder (CAFE), a method allowing precise, real-time measurement of ingestion by individual or grouped fruit flies on the scale of minutes to days. Using this technique, we conducted the first quantitative analysis of prandial behavior in Drosophila melanogaster . Our results allow the dissection of feeding into discrete bouts of ingestion, defining two separate parameters, meal volume and frequency, that can be uncoupled and thus are likely to be independently regulated. In addition, our long-term measurements show that flies can ingest as much as 1.7× their body mass over 24 h. Besides the study of appetite, the CAFE can be used to monitor oral drug delivery. As an illustration, we used the CAFE to test the effects of dietary supplementation with two compounds, paraquat and ethanol, on food ingestion and preference. Paraquat, a prooxidant widely used in stress tests, had a strong anorexigenic effect. In contrast, in a feeding preference assay, ethanol-laced food, but not ethanol by itself, acted as an attractant.
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Cites
Sirtuin activators mimic caloric restriction and delay ageing in metazoans
Wood, J. G., Rogina, B., Lavu, S., Howitz, K., Helfand, S. L., Tatar, M., & Sinclair, D. (2004) · Nature · doi:10.1038/nature02789 · Cited by 1,868
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Lifespan and reproduction in Drosophila : New insights from nutritional geometry
Lee, K. P., Simpson, S. J., Clissold, F. J., Brooks, R., Ballard, J. W. O., Taylor, P. W., Soran, N., & Raubenheimer, D. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0710787105 · Cited by 1,032
FOXO/4E-BP Signaling in Drosophila Muscles Regulates Organism-wide Proteostasis during Aging
Demontis, F., & Perrimon, N. (2010) · Cell · doi:10.1016/j.cell.2010.10.007 · Cited by 656
Clark, R. I., Salazar, A., Yamada, R., Fitz-Gibbon, S., Morselli, M., Alcaraz, J., Rana, A., Rera, M., Pellegrini, M., Ja, W. W., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.08.004 · Cited by 510
Self-citationMethods for studying metabolism in Drosophila
Tennessen, J. M., Barry, W. E., Cox, J., & Thummel, C. S. (2014) · Methods · doi:10.1016/j.ymeth.2014.02.034 · Cited by 445
Paternal Diet Defines Offspring Chromatin State and Intergenerational Obesity
Öst, A., Lempradl, A., Casas, E., Weigert, M., Tiko, T., Deniz, M., Pantano, L., Boenisch, U., Itskov, P. M., Stoeckius, M., et al. (2014) · Cell · doi:10.1016/j.cell.2014.11.005 · Cited by 406
Metadata
- Authors
- Ja, W. W., Carvalho, G. B., Mak, E. M., de la Rosa, N. N., Fang, A. Y., Liong, J. C., Brummel, T., & Benzer, S.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2007-05-15
- Volume
- 104
- Issue
- 20
- Pages
- 8253-8256
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2157765869
- Cited by
- 701
- References
- 1
- FWCI
- 4.96
- Type
- journal article
- Language
- en
- Open access
- green
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- Ja, W. W., Carvalho, G. B., Mak, E. M., de la Rosa, N. N., Fang, A. Y., Liong, J. C., Brummel, T., & Benzer, S. (2007). Prandiology of Drosophila and the CAFE assay. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0702726104
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