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Cited by 388

The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.

Dissociation of the insulin receptor and caveolin-1 complex by ganglioside GM3 in the state of insulin resistance

Open access
Kabayama, Kazuya, Sato, Takashige, Saito, Kumiko, Loberto, Nicoletta, Prinetti, Alessandro, Sonnino, Sandro, Kinjo, Masataka, Igarashi, Yasuyuki, Inokuchi, Jin-ichi·2007·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.0703650104
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Abstract

Membrane microdomains (lipid rafts) are now recognized as critical for proper compartmentalization of insulin signaling. We previously demonstrated that, in adipocytes in a state of TNFα-induced insulin resistance, the inhibition of insulin metabolic signaling and the elimination of insulin receptors (IR) from the caveolae microdomains were associated with an accumulation of the ganglioside GM3. To gain insight into molecular mechanisms behind interactions of IR, caveolin-1 (Cav1), and GM3 in adipocytes, we have performed immunoprecipitations, cross-linking studies of IR and GM3, and live cell studies using total internal reflection fluorescence microscopy and fluorescence recovery after photobleaching techniques. We found that ( i ) IR form complexes with Cav1 and GM3 independently; ( ii ) in GM3-enriched membranes the mobility of IR is increased by dissociation of the IR–Cav1 interaction; and ( iii ) the lysine residue localized just above the transmembrane domain of the IR β-subunit is essential for the interaction of IR with GM3. Because insulin metabolic signal transduction in adipocytes is known to be critically dependent on caveolae, we propose a pathological feature of insulin resistance in adipocytes caused by dissociation of the IR–Cav1 complex by the interactions of IR with GM3 in microdomains.

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Metadata

Authors
Kabayama, K., Sato, T., Saito, K., Loberto, N., Prinetti, A., Sonnino, S., Kinjo, M., Igarashi, Y., & Inokuchi, J.-I.
Venue
Proceedings of the National Academy of Sciences
Publisher
Proceedings of the National Academy of Sciences
Published
2007-08-21
Volume
104
Issue
34
Pages
13678-13683
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.0703650104
OpenAlex
W1966316647
Cited by
388
References
43
FWCI
7.07
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Dissociation of the insulin receptor and caveolin-1 complex by ganglioside GM3 in the state of insulin resistance. https://app.cochat.ai/papers/10.1073/pnas.0703650104
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Kabayama, K., Sato, T., Saito, K., Loberto, N., Prinetti, A., Sonnino, S., Kinjo, M., Igarashi, Y., & Inokuchi, J.-I. (2007). Dissociation of the insulin receptor and caveolin-1 complex by ganglioside GM3 in the state of insulin resistance. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0703650104

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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