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Noise in solid-state nanopores
Open accessAbstract
We study ionic current fluctuations in solid-state nanopores over a wide frequency range and present a complete description of the noise characteristics. At low frequencies ( f ≲ 100 Hz) we observe 1/ f -type of noise. We analyze this low-frequency noise at different salt concentrations and find that the noise power remarkably scales linearly with the inverse number of charge carriers, in agreement with Hooge's relation. We find a Hooge parameter α = (1.1 ± 0.1) × 10 −4 . In the high-frequency regime ( f ≳ 1 kHz), we can model the increase in current power spectral density with frequency through a calculation of the Johnson noise. Finally, we use these results to compute the signal-to-noise ratio for DNA translocation for different salt concentrations and nanopore diameters, yielding the parameters for optimal detection efficiency.
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Cited by
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Kavokine, N., Netz, R. R., & Bocquet, L. (2021) · Annual Review of Fluid Mechanics · doi:10.1146/annurev-fluid-071320-095958 · Cited by 389
DNA Base Detection Using a Single-Layer MoS2
Farimani, A. B., Min, K., & Aluru, N. R. (2014) · ACS Nano · doi:10.1021/nn5029295 · Cited by 355
Digitally encoded DNA nanostructures for multiplexed, single-molecule protein sensing with nanopores
Bell, N. A. W., & Keyser, U. F. (2016) · Nature Nanotechnology · doi:10.1038/nnano.2016.50 · Cited by 345
Self-citationMulti-resolution simulation of DNA transport through large synthetic nanostructures
Choudhary, A., Maffeo, C., & Aksimentiev, A. (2022) · Physical Chemistry Chemical Physics · doi:10.1039/d1cp04589j · Cited by 22
Metadata
- Authors
- Smeets, R. M. M., Keyser, U. F., Dekker, N. H., & Dekker, C.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2008-01-15
- Volume
- 105
- Issue
- 2
- Pages
- 417-421
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2100085677
- Cited by
- 374
- References
- 0
- FWCI
- 8.95
- Type
- journal article
- Language
- en
- Open access
- green
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- Smeets, R. M. M., Keyser, U. F., Dekker, N. H., & Dekker, C. (2008). Noise in solid-state nanopores. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0705349105
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