The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Aquatic eutrophication promotes pathogenic infection in amphibians
Open accessAbstract
The widespread emergence of human and wildlife diseases has challenged ecologists to understand how large-scale agents of environmental change affect host–pathogen interactions. Accelerated eutrophication of aquatic ecosystems owing to nitrogen and phosphorus enrichment is a pervasive form of environmental change that has been implicated in the emergence of diseases through direct and indirect pathways. We provide experimental evidence linking eutrophication and disease in a multihost parasite system. The trematode parasite Ribeiroia ondatrae sequentially infects birds, snails, and amphibian larvae, frequently causing severe limb deformities and mortality. Eutrophication has been implicated in the emergence of this parasite, but definitive evidence, as well as a mechanistic understanding, have been lacking until now. We show that the effects of eutrophication cascade through the parasite life cycle to promote algal production, the density of snail hosts, and, ultimately, the intensity of infection in amphibians. Infection also negatively affected the survival of developing amphibians. Mechanistically, eutrophication promoted amphibian disease through two distinctive pathways: by increasing the density of infected snail hosts and by enhancing per-snail production of infectious parasites. Given forecasted increases in global eutrophication, amphibian extinctions, and similarities between Ribeiroia and important human and wildlife pathogens, our results have broad epidemiological and ecological significance.
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Cites
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Self-citationParasites dominate food web links
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Nutrient enrichment can increase the severity of coral diseases
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Cited by
The cause of global amphibian declines: a developmental endocrinologist's perspective
Hayes, T. B., Falso, P., Gallipeau, S., & Stice, M. (2010) · Journal of Experimental Biology · doi:10.1242/jeb.040865 · Cited by 451
Direct and Indirect Effects of Climate Change on Amphibian Populations
Blaustein, A. R., Walls, S. C., Bancroft, B. A., Lawler, J. J., Searle, C. L., & Gervasi, S. S. (2010) · Diversity · doi:10.3390/d2020281 · Cited by 420
A review of the species, community, and ecosystem impacts of road salt salinisation in fresh waters
Hintz, W. D., & Relyea, R. A. (2019) · Freshwater Biology · doi:10.1111/fwb.13286 · Cited by 324
UNDERSTANDING THE NET EFFECTS OF PESTICIDES ON AMPHIBIAN TREMATODE INFECTIONS
Rohr, J. R., Raffel, T. R., Sessions, S. K., & Hudson, P. J. (2008) · Ecological Applications · doi:10.1890/07-1429.1 · Cited by 209
Ecophysiology meets conservation: understanding the role of disease in amphibian population declines
Blaustein, A. R., Gervasi, S. S., Johnson, P. T. J., Hoverman, J. T., Belden, L. K., Bradley, P. W., & Xie, G. Y. (2012) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2012.0011 · Cited by 168
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Metadata
- Authors
- Johnson, P. T. J., Chase, J. M., Dosch, K. L., Hartson, R. B., Gross, J. A., Larson, D. J., Sutherland, D. R., & Carpenter, S. R.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2007-10-02
- Volume
- 104
- Issue
- 40
- Pages
- 15781-15786
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2111982541
- Cited by
- 384
- References
- 30
- FWCI
- 17.06
- Type
- journal article
- Language
- en
- Open access
- green
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- Johnson, P. T. J., Chase, J. M., Dosch, K. L., Hartson, R. B., Gross, J. A., Larson, D. J., Sutherland, D. R., & Carpenter, S. R. (2007). Aquatic eutrophication promotes pathogenic infection in amphibians. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0707763104
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